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STRINGSTRING
PITX1 PITX1 TTC6 TTC6 CARD14 CARD14 SLC25A21 SLC25A21 MIPOL1 MIPOL1 FOXC1 FOXC1 PITX2 PITX2 LSS LSS CCT3 CCT3 ARNT2 ARNT2 DLX2 DLX2
"MIPOL1" - mirror-image polydactyly 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MIPOL1mirror-image polydactyly 1 (442 aa)    
Predicted Functional Partners:
LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (732 aa)
            score_image   0.756
SLC25A21
solute carrier family 25 (mitochondrial oxoadipate carrier), member 21; Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate (299 aa)
            score_image   0.700
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2; Specifically recognizes the xenobiotic response element (XRE) (717 aa)
        score_image       0.691
TTC6
tetratricopeptide repeat domain 6 (1886 aa)
            score_image   0.639
PITX2
paired-like homeodomain 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity) (324 aa)
            score_image   0.609
CCT3
chaperonin containing TCP1, subunit 3 (gamma); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (545 aa)
        score_image       0.549
CARD14
caspase recruitment domain family, member 14; Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 (1004 aa)
            score_image   0.513
PITX1
paired-like homeodomain 1; May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb (314 aa)
            score_image   0.489
FOXC1
forkhead box C1; Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5’- GTAAACAAA-3’ in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (553 aa)
            score_image   0.440
DLX2
distal-less homeobox 2; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis (328 aa)
            score_image   0.439
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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