node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARNT2 | MIPOL1 | ENSP00000307479 | ENSP00000333539 | aryl-hydrocarbon receptor nuclear translocator 2; Specifically recognizes the xenobiotic response element (XRE) | mirror-image polydactyly 1 | 0.691 |
CARD14 | MIPOL1 | ENSP00000344549 | ENSP00000333539 | caspase recruitment domain family, member 14; Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 | mirror-image polydactyly 1 | 0.513 |
CCT3 | MIPOL1 | ENSP00000295688 | ENSP00000333539 | chaperonin containing TCP1, subunit 3 (gamma); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | mirror-image polydactyly 1 | 0.549 |
DLX2 | MIPOL1 | ENSP00000234198 | ENSP00000333539 | distal-less homeobox 2; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis | mirror-image polydactyly 1 | 0.439 |
FOXC1 | MIPOL1 | ENSP00000370256 | ENSP00000333539 | forkhead box C1; Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5’- GTAAACAAA-3’ in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye | mirror-image polydactyly 1 | 0.440 |
FOXC1 | PITX2 | ENSP00000370256 | ENSP00000304169 | forkhead box C1; Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5’- GTAAACAAA-3’ in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye | paired-like homeodomain 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity) | 0.979 |
LSS | MIPOL1 | ENSP00000348762 | ENSP00000333539 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | mirror-image polydactyly 1 | 0.756 |
MIPOL1 | ARNT2 | ENSP00000333539 | ENSP00000307479 | mirror-image polydactyly 1 | aryl-hydrocarbon receptor nuclear translocator 2; Specifically recognizes the xenobiotic response element (XRE) | 0.691 |
MIPOL1 | CARD14 | ENSP00000333539 | ENSP00000344549 | mirror-image polydactyly 1 | caspase recruitment domain family, member 14; Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 | 0.513 |
MIPOL1 | CCT3 | ENSP00000333539 | ENSP00000295688 | mirror-image polydactyly 1 | chaperonin containing TCP1, subunit 3 (gamma); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | 0.549 |
MIPOL1 | DLX2 | ENSP00000333539 | ENSP00000234198 | mirror-image polydactyly 1 | distal-less homeobox 2; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis | 0.439 |
MIPOL1 | FOXC1 | ENSP00000333539 | ENSP00000370256 | mirror-image polydactyly 1 | forkhead box C1; Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5’- GTAAACAAA-3’ in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye | 0.440 |
MIPOL1 | LSS | ENSP00000333539 | ENSP00000348762 | mirror-image polydactyly 1 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.756 |
MIPOL1 | PITX1 | ENSP00000333539 | ENSP00000265340 | mirror-image polydactyly 1 | paired-like homeodomain 1; May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb | 0.489 |
MIPOL1 | PITX2 | ENSP00000333539 | ENSP00000304169 | mirror-image polydactyly 1 | paired-like homeodomain 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity) | 0.609 |
MIPOL1 | SLC25A21 | ENSP00000333539 | ENSP00000329452 | mirror-image polydactyly 1 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21; Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate | 0.700 |
MIPOL1 | TTC6 | ENSP00000333539 | ENSP00000451131 | mirror-image polydactyly 1 | tetratricopeptide repeat domain 6 | 0.639 |
PITX1 | MIPOL1 | ENSP00000265340 | ENSP00000333539 | paired-like homeodomain 1; May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb | mirror-image polydactyly 1 | 0.489 |
PITX2 | FOXC1 | ENSP00000304169 | ENSP00000370256 | paired-like homeodomain 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity) | forkhead box C1; Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5’- GTAAACAAA-3’ in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye | 0.979 |
PITX2 | MIPOL1 | ENSP00000304169 | ENSP00000333539 | paired-like homeodomain 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity) | mirror-image polydactyly 1 | 0.609 |