Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | PROSC | proline synthetase co-transcribed homolog (bacterial) (275 aa) | ||||||||||||
Predicted Functional Partners:
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 | WHSC1L1 | Wolf-Hirschhorn syndrome candidate 1-like 1 (1437 aa) |
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0.677 | ||||||||||
 | PDIA4 | protein disulfide isomerase family A, member 4 (645 aa) |
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0.608 | |||||||||
 | TATDN1 | TatD DNase domain containing 1; Putative deoxyribonuclease (By similarity) (297 aa) |
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0.593 | |||||||
 | P5CR2 | Uncharacterized protein (359 aa) |
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0.593 | ||||||||
 | NOXRED1 | NADP-dependent oxidoreductase domain containing 1; Probable oxidoreductase (By similarity) (359 aa) |
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0.593 | ||||||||
 | PYCR2 | pyrroline-5-carboxylate reductase family, member 2; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (320 aa) |
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0.593 | ||||||||
 | PYCR1 | pyrroline-5-carboxylate reductase 1; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress (319 aa) |
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0.593 | ||||||||
 | PYCRL | pyrroline-5-carboxylate reductase-like (286 aa) |
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0.593 | ||||||||
 | ERLIN2 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway (339 aa) |
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0.587 | ||||||||||
 | ZNF703 | zinc finger protein 703; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development (590 aa) |
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0.581 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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