node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BSCL2 | PRPS1 | ENSP00000354032 | ENSP00000361512 | Berardinelli-Seip congenital lipodystrophy 2 (seipin); Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues | phosphoribosyl pyrophosphate synthetase 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis | 0.473 |
BSCL2 | SLC52A2 | ENSP00000354032 | ENSP00000333638 | Berardinelli-Seip congenital lipodystrophy 2 (seipin); Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues | solute carrier family 52, riboflavin transporter, member 2; Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A) | 0.436 |
CMTM8 | SLC12A7 | ENSP00000307741 | ENSP00000264930 | CKLF-like MARVEL transmembrane domain containing 8 | solute carrier family 12 (potassium/chloride transporters), member 7; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters’ cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity) | 0.405 |
CMTM8 | SLC52A2 | ENSP00000307741 | ENSP00000333638 | CKLF-like MARVEL transmembrane domain containing 8 | solute carrier family 52, riboflavin transporter, member 2; Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A) | 0.427 |
GPR107 | GPR137 | ENSP00000361483 | ENSP00000411827 | G protein-coupled receptor 107 | G protein-coupled receptor 137 | 0.672 |
GPR107 | GPR149 | ENSP00000361483 | ENSP00000374390 | G protein-coupled receptor 107 | G protein-coupled receptor 149; Orphan receptor | 0.719 |
GPR107 | PAQR8 | ENSP00000361483 | ENSP00000353953 | G protein-coupled receptor 107 | progestin and adipoQ receptor family member VIII; Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity) | 0.662 |
GPR107 | SLC52A2 | ENSP00000361483 | ENSP00000333638 | G protein-coupled receptor 107 | solute carrier family 52, riboflavin transporter, member 2; Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A) | 0.654 |
GPR107 | TMEM185A | ENSP00000361483 | ENSP00000359449 | G protein-coupled receptor 107 | transmembrane protein 185A | 0.802 |
GPR108 | GPR137 | ENSP00000264080 | ENSP00000411827 | G protein-coupled receptor 108 | G protein-coupled receptor 137 | 0.694 |
GPR108 | GPR149 | ENSP00000264080 | ENSP00000374390 | G protein-coupled receptor 108 | G protein-coupled receptor 149; Orphan receptor | 0.680 |
GPR108 | PAQR8 | ENSP00000264080 | ENSP00000353953 | G protein-coupled receptor 108 | progestin and adipoQ receptor family member VIII; Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity) | 0.630 |
GPR108 | SLC52A2 | ENSP00000264080 | ENSP00000333638 | G protein-coupled receptor 108 | solute carrier family 52, riboflavin transporter, member 2; Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A) | 0.620 |
GPR108 | TMEM185A | ENSP00000264080 | ENSP00000359449 | G protein-coupled receptor 108 | transmembrane protein 185A | 0.770 |
GPR137 | GPR107 | ENSP00000411827 | ENSP00000361483 | G protein-coupled receptor 137 | G protein-coupled receptor 107 | 0.672 |
GPR137 | GPR108 | ENSP00000411827 | ENSP00000264080 | G protein-coupled receptor 137 | G protein-coupled receptor 108 | 0.694 |
GPR137 | GPR149 | ENSP00000411827 | ENSP00000374390 | G protein-coupled receptor 137 | G protein-coupled receptor 149; Orphan receptor | 0.580 |
GPR137 | PAQR8 | ENSP00000411827 | ENSP00000353953 | G protein-coupled receptor 137 | progestin and adipoQ receptor family member VIII; Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity) | 0.616 |
GPR137 | SLC52A2 | ENSP00000411827 | ENSP00000333638 | G protein-coupled receptor 137 | solute carrier family 52, riboflavin transporter, member 2; Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A) | 0.436 |
GPR137 | TMEM185A | ENSP00000411827 | ENSP00000359449 | G protein-coupled receptor 137 | transmembrane protein 185A | 0.630 |