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IL3RA IL3RA IL21R IL21R IL20RA IL20RA IL28A IL28A IL22RA1 IL22RA1 IL28RA IL28RA IL10RA IL10RA IFNGR1 IFNGR1 IFNAR1 IFNAR1 IL10RB IL10RB IL22RA2 IL22RA2
"IL28A" - interleukin 28A (interferon, lambda 2) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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IL28Ainterleukin 28A (interferon, lambda 2); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...] (200 aa)    
Predicted Functional Partners:
IL28RA
interleukin 28 receptor, alpha (interferon, lambda receptor); The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium (520 aa)
        score_image score_image score_image   0.979
IFNAR1
interferon (alpha, beta and omega) receptor 1; Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves (557 aa)
          score_image score_image   0.928
IL22RA2
interleukin 22 receptor, alpha 2; Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses (263 aa)
          score_image score_image   0.914
IL20RA
interleukin 20 receptor, alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (553 aa)
          score_image score_image   0.908
IL22RA1
interleukin 22 receptor, alpha 1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation (574 aa)
          score_image score_image   0.883
IL10RB
interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 (325 aa)
        score_image   score_image   0.874
IL10RA
interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity (578 aa)
          score_image score_image   0.874
IFNGR1
interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer (489 aa)
          score_image score_image   0.852
IL3RA
interleukin 3 receptor, alpha (low affinity); This is a receptor for interleukin-3 (378 aa)
          score_image score_image   0.815
IL21R
interleukin 21 receptor; This is a receptor for interleukin-21 (538 aa)
          score_image score_image   0.814
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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