node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAA1 | ACADM | ENSP00000333664 | ENSP00000409612 | acetyl-CoA acyltransferase 1 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | 0.975 |
ACAA1 | ACADVL | ENSP00000333664 | ENSP00000349297 | acetyl-CoA acyltransferase 1 | acyl-CoA dehydrogenase, very long chain; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons | 0.971 |
ACAA1 | ACOX1 | ENSP00000333664 | ENSP00000293217 | acetyl-CoA acyltransferase 1 | acyl-CoA oxidase 1, palmitoyl | 0.995 |
ACAA1 | ACOX3 | ENSP00000333664 | ENSP00000348775 | acetyl-CoA acyltransferase 1 | acyl-CoA oxidase 3, pristanoyl; Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity) | 0.992 |
ACAA1 | EHHADH | ENSP00000333664 | ENSP00000231887 | acetyl-CoA acyltransferase 1 | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.998 |
ACAA1 | HADH | ENSP00000333664 | ENSP00000385638 | acetyl-CoA acyltransferase 1 | hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA | 0.984 |
ACAA1 | HADHA | ENSP00000333664 | ENSP00000370023 | acetyl-CoA acyltransferase 1 | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.999 |
ACAA1 | HMGCS1 | ENSP00000333664 | ENSP00000322706 | acetyl-CoA acyltransferase 1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.984 |
ACAA1 | HMGCS2 | ENSP00000333664 | ENSP00000358414 | acetyl-CoA acyltransferase 1 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.986 |
ACAA1 | HSD17B4 | ENSP00000333664 | ENSP00000420914 | acetyl-CoA acyltransferase 1 | hydroxysteroid (17-beta) dehydrogenase 4; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids | 0.998 |
ACADM | ACAA1 | ENSP00000409612 | ENSP00000333664 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | acetyl-CoA acyltransferase 1 | 0.975 |
ACADM | ACOX1 | ENSP00000409612 | ENSP00000293217 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | acyl-CoA oxidase 1, palmitoyl | 0.643 |
ACADM | ACOX3 | ENSP00000409612 | ENSP00000348775 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | acyl-CoA oxidase 3, pristanoyl; Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity) | 0.525 |
ACADM | EHHADH | ENSP00000409612 | ENSP00000231887 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.993 |
ACADM | HADH | ENSP00000409612 | ENSP00000385638 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA | 0.783 |
ACADM | HADHA | ENSP00000409612 | ENSP00000370023 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.994 |
ACADM | HMGCS2 | ENSP00000409612 | ENSP00000358414 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.475 |
ACADM | HSD17B4 | ENSP00000409612 | ENSP00000420914 | acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16 | hydroxysteroid (17-beta) dehydrogenase 4; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids | 0.509 |
ACADVL | ACAA1 | ENSP00000349297 | ENSP00000333664 | acyl-CoA dehydrogenase, very long chain; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons | acetyl-CoA acyltransferase 1 | 0.971 |
ACADVL | ACOX1 | ENSP00000349297 | ENSP00000293217 | acyl-CoA dehydrogenase, very long chain; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons | acyl-CoA oxidase 1, palmitoyl | 0.555 |