Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 (234 aa) | ||||||||||||
Predicted Functional Partners:
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 | CMTM3 | CKLF-like MARVEL transmembrane domain containing 3 (182 aa) |
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0.868 | ||||||||||
 | CMTM1 | CKLF-like MARVEL transmembrane domain containing 1 (286 aa) |
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0.867 | ||||||||||
 | CMTM2 | CKLF-like MARVEL transmembrane domain containing 2 (248 aa) |
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0.867 | ||||||||||
 | CKLF | chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10 (152 aa) |
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0.864 | ||||||||||
 | CMTM5 | CKLF-like MARVEL transmembrane domain containing 5 (156 aa) |
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0.744 | ||||||||||
 | SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans); GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (735 aa) |
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0.573 | ||||||||||
 | C3orf33 | chromosome 3 open reading frame 33 (251 aa) |
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0.466 | ||||||||||
 | SCAF4 | SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity) (1147 aa) |
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0.464 | ||||||||||
 | MITD1 | MIT, microtubule interacting and transport, domain containing 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex (249 aa) |
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0.464 | ||||||||||
 | PPAP2C | phosphatidic acid phosphatase type 2C; Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P (309 aa) |
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0.454 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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