node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRIX1 | ENSG00000248354 | ENSP00000338862 | ENSP00000415634 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | Uncharacterized protein | 0.896 |
BRIX1 | ENSG00000268412 | ENSP00000338862 | ENSP00000472299 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | Uncharacterized protein | 0.412 |
BRIX1 | GTPBP4 | ENSP00000338862 | ENSP00000354040 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | 0.988 |
BRIX1 | NOP2 | ENSP00000338862 | ENSP00000382392 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.994 |
BRIX1 | NSUN6 | ENSP00000338862 | ENSP00000366519 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | 0.986 |
BRIX1 | PWP2 | ENSP00000338862 | ENSP00000291576 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | PWP2 periodic tryptophan protein homolog (yeast) | 0.897 |
BRIX1 | TRMT1 | ENSP00000338862 | ENSP00000350352 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups | 0.736 |
BRIX1 | TRMT11 | ENSP00000338862 | ENSP00000333934 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity) | 0.842 |
BRIX1 | TRMT112 | ENSP00000338862 | ENSP00000438349 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | tRNA methyltransferase 11-2 homolog (S. cerevisiae); Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5- methylation of ETF1 on ’Gln-185’, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species | 0.412 |
BRIX1 | WDR12 | ENSP00000338862 | ENSP00000261015 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.998 |
ENSG00000248354 | BRIX1 | ENSP00000415634 | ENSP00000338862 | Uncharacterized protein | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | 0.896 |
ENSG00000248354 | GTPBP4 | ENSP00000415634 | ENSP00000354040 | Uncharacterized protein | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | 0.894 |
ENSG00000248354 | NOP2 | ENSP00000415634 | ENSP00000382392 | Uncharacterized protein | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.941 |
ENSG00000248354 | NSUN6 | ENSP00000415634 | ENSP00000366519 | Uncharacterized protein | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | 0.941 |
ENSG00000248354 | TRMT1 | ENSP00000415634 | ENSP00000350352 | Uncharacterized protein | tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups | 0.740 |
ENSG00000248354 | TRMT11 | ENSP00000415634 | ENSP00000333934 | Uncharacterized protein | tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity) | 0.869 |
ENSG00000248354 | WDR12 | ENSP00000415634 | ENSP00000261015 | Uncharacterized protein | WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.969 |
ENSG00000268412 | BRIX1 | ENSP00000472299 | ENSP00000338862 | Uncharacterized protein | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | 0.412 |
ENSG00000268412 | TRMT11 | ENSP00000472299 | ENSP00000333934 | Uncharacterized protein | tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity) | 0.914 |
ENSG00000268412 | WDR12 | ENSP00000472299 | ENSP00000261015 | Uncharacterized protein | WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.432 |