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ENSG00000268412 ENSG00000268412 ENSG00000248354 ENSG00000248354 TRMT11 TRMT11 WDR12 WDR12 TRMT112 TRMT112 NSUN6 NSUN6 BRIX1 BRIX1 NOP2 NOP2 GTPBP4 GTPBP4 TRMT1 TRMT1 PWP2 PWP2
"TRMT11" - tRNA methyltransferase 11 homolog (S. cerevisiae) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
TRMT11tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity) (463 aa)    
Predicted Functional Partners:
TRMT112
tRNA methyltransferase 11-2 homolog (S. cerevisiae); Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5- methylation of ETF1 on ’Gln-185’, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (125 aa)
      score_image score_image   score_image   0.958
ENSG00000268412
Uncharacterized protein (135 aa)
      score_image score_image   score_image   0.914
TRMT1
tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (659 aa)
      score_image score_image   score_image   0.877
GTPBP4
GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) (634 aa)
      score_image     score_image   0.877
ENSG00000248354
Uncharacterized protein (205 aa)
      score_image         0.869
PWP2
PWP2 periodic tryptophan protein homolog (yeast) (919 aa)
      score_image         0.869
WDR12
WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (423 aa)
      score_image         0.868
BRIX1
BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit (353 aa)
      score_image         0.842
NOP2
NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase (808 aa)
      score_image score_image   score_image   0.831
NSUN6
NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) (469 aa)
      score_image score_image   score_image   0.829
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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