RPS19BP1 protein (Homo sapiens) - STRING network view

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RPS19BP1

ribosomal protein S19 binding protein 1; Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (136 aa)

Predicted Functional Partners:

SIRT1

0.998

RPS19

0.944

MRPL18

0.904

DEDD2

0.900

COL4A6

0.900

SERPINH1

0.900

CRYBA4

0.900

HSPH1

0.900

HSPA6

0.900

UBB

0.900

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL4A6	CRYBA4	ENSP00000361290	ENSP00000346805	collagen, type IV, alpha 6	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	0.900
COL4A6	DEDD2	ENSP00000361290	ENSP00000470082	collagen, type IV, alpha 6	death effector domain containing 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3	0.900
COL4A6	HSPA6	ENSP00000361290	ENSP00000310219	collagen, type IV, alpha 6	heat shock 70kDa protein 6 (HSP70B’); In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity)	0.905
COL4A6	HSPH1	ENSP00000361290	ENSP00000318687	collagen, type IV, alpha 6	heat shock 105kDa/110kDa protein 1; Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity)	0.900
COL4A6	MRPL18	ENSP00000361290	ENSP00000356001	collagen, type IV, alpha 6	mitochondrial ribosomal protein L18; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA	0.900
COL4A6	RPS19BP1	ENSP00000361290	ENSP00000333948	collagen, type IV, alpha 6	ribosomal protein S19 binding protein 1; Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity	0.900
COL4A6	SERPINH1	ENSP00000361290	ENSP00000350894	collagen, type IV, alpha 6	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen	0.903
COL4A6	SIRT1	ENSP00000361290	ENSP00000212015	collagen, type IV, alpha 6	sirtuin 1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Se [...]	0.900
COL4A6	UBB	ENSP00000361290	ENSP00000304697	collagen, type IV, alpha 6	ubiquitin B	0.900
CRYBA4	COL4A6	ENSP00000346805	ENSP00000361290	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	collagen, type IV, alpha 6	0.900
CRYBA4	DEDD2	ENSP00000346805	ENSP00000470082	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	death effector domain containing 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3	0.900
CRYBA4	HSPA6	ENSP00000346805	ENSP00000310219	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	heat shock 70kDa protein 6 (HSP70B’); In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity)	0.900
CRYBA4	HSPH1	ENSP00000346805	ENSP00000318687	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	heat shock 105kDa/110kDa protein 1; Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity)	0.903
CRYBA4	MRPL18	ENSP00000346805	ENSP00000356001	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	mitochondrial ribosomal protein L18; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA	0.900
CRYBA4	RPS19BP1	ENSP00000346805	ENSP00000333948	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	ribosomal protein S19 binding protein 1; Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity	0.900
CRYBA4	SERPINH1	ENSP00000346805	ENSP00000350894	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen	0.900
CRYBA4	SIRT1	ENSP00000346805	ENSP00000212015	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	sirtuin 1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Se [...]	0.900
CRYBA4	UBB	ENSP00000346805	ENSP00000304697	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	ubiquitin B	0.900
DEDD2	COL4A6	ENSP00000470082	ENSP00000361290	death effector domain containing 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3	collagen, type IV, alpha 6	0.900
DEDD2	CRYBA4	ENSP00000470082	ENSP00000346805	death effector domain containing 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	0.900

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