node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHSP | HBA1 | ENSP00000307199 | ENSP00000322421 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity) | 0.973 |
AHSP | HBA2 | ENSP00000307199 | ENSP00000251595 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | hemoglobin, alpha 2 | 0.996 |
AHSP | HBB | ENSP00000307199 | ENSP00000333994 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | hemoglobin, beta | 0.951 |
AHSP | HBG2 | ENSP00000307199 | ENSP00000338082 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains | 0.510 |
AHSP | HBZ | ENSP00000307199 | ENSP00000252951 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | hemoglobin, zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac | 0.748 |
AHSP | KLF1 | ENSP00000307199 | ENSP00000264834 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...] | 0.921 |
AQP1 | HBB | ENSP00000311165 | ENSP00000333994 | aquaporin 1 (Colton blood group); Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient | hemoglobin, beta | 0.935 |
AQP1 | KLF1 | ENSP00000311165 | ENSP00000264834 | aquaporin 1 (Colton blood group); Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient | Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...] | 0.513 |
HBA1 | AHSP | ENSP00000322421 | ENSP00000307199 | hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity) | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | 0.973 |
HBA1 | HBA2 | ENSP00000322421 | ENSP00000251595 | hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity) | hemoglobin, alpha 2 | 0.900 |
HBA1 | HBB | ENSP00000322421 | ENSP00000333994 | hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity) | hemoglobin, beta | 0.999 |
HBA1 | HBG2 | ENSP00000322421 | ENSP00000338082 | hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity) | hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains | 0.830 |
HBA1 | HBZ | ENSP00000322421 | ENSP00000252951 | hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity) | hemoglobin, zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac | 0.760 |
HBA1 | HP | ENSP00000322421 | ENSP00000348170 | hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity) | haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation [...] | 0.935 |
HBA1 | KLF1 | ENSP00000322421 | ENSP00000264834 | hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity) | Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...] | 0.540 |
HBA2 | AHSP | ENSP00000251595 | ENSP00000307199 | hemoglobin, alpha 2 | alpha hemoglobin stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia | 0.996 |
HBA2 | HBA1 | ENSP00000251595 | ENSP00000322421 | hemoglobin, alpha 2 | hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity) | 0.900 |
HBA2 | HBB | ENSP00000251595 | ENSP00000333994 | hemoglobin, alpha 2 | hemoglobin, beta | 0.997 |
HBA2 | HBG2 | ENSP00000251595 | ENSP00000338082 | hemoglobin, alpha 2 | hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains | 0.982 |
HBA2 | HBZ | ENSP00000251595 | ENSP00000252951 | hemoglobin, alpha 2 | hemoglobin, zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac | 0.758 |