node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHI1 | HAP1 | ENSP00000265602 | ENSP00000334002 | Abelson helper integration site 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity) | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | 0.953 |
AR | BDNF | ENSP00000363822 | ENSP00000414303 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | brain-derived neurotrophic factor | 0.874 |
AR | HAP1 | ENSP00000363822 | ENSP00000334002 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | 0.846 |
BDNF | AR | ENSP00000414303 | ENSP00000363822 | brain-derived neurotrophic factor | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.874 |
BDNF | HAP1 | ENSP00000414303 | ENSP00000334002 | brain-derived neurotrophic factor | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | 0.885 |
BDNF | HTT | ENSP00000414303 | ENSP00000347184 | brain-derived neurotrophic factor | huntingtin; May play a role in microtubule-mediated transport or vesicle function | 0.903 |
BDNF | KALRN | ENSP00000414303 | ENSP00000240874 | brain-derived neurotrophic factor | kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity | 0.407 |
BDNF | YWHAZ | ENSP00000414303 | ENSP00000309503 | brain-derived neurotrophic factor | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.847 |
DCTN1 | HAP1 | ENSP00000354791 | ENSP00000334002 | dynactin 1 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | 0.843 |
HAP1 | AHI1 | ENSP00000334002 | ENSP00000265602 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | Abelson helper integration site 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity) | 0.953 |
HAP1 | AR | ENSP00000334002 | ENSP00000363822 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.846 |
HAP1 | BDNF | ENSP00000334002 | ENSP00000414303 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | brain-derived neurotrophic factor | 0.885 |
HAP1 | DCTN1 | ENSP00000334002 | ENSP00000354791 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | dynactin 1 | 0.843 |
HAP1 | HGS | ENSP00000334002 | ENSP00000331201 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.941 |
HAP1 | HSPA4 | ENSP00000334002 | ENSP00000302961 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | heat shock 70kDa protein 4 | 0.840 |
HAP1 | HTT | ENSP00000334002 | ENSP00000347184 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | huntingtin; May play a role in microtubule-mediated transport or vesicle function | 0.981 |
HAP1 | KALRN | ENSP00000334002 | ENSP00000240874 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity | 0.935 |
HAP1 | NFYB | ENSP00000334002 | ENSP00000240055 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | nuclear transcription factor Y, beta; Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes | 0.942 |
HAP1 | YWHAZ | ENSP00000334002 | ENSP00000309503 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.848 |
HGS | HAP1 | ENSP00000331201 | ENSP00000334002 | hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | 0.941 |