KLHDC10 protein (Homo sapiens) - STRING network view

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KLHDC10

kelch domain containing 10 (442 aa)

Predicted Functional Partners:

CUL2

0.999

USP7

0.999

SH3GLB1

0.704

KBTBD13

0.669

MEGF10

0.662

KLHDC7A

0.618

MEGF6

0.613

MEGF11

0.612

PEAR1

0.601

CORO2B

0.585

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CORO2B	KLHDC10	ENSP00000454783	ENSP00000334140	coronin, actin binding protein, 2B; May play a role in the reorganization of neuronal actin structure	kelch domain containing 10	0.585
CORO2B	MEGF10	ENSP00000454783	ENSP00000274473	coronin, actin binding protein, 2B; May play a role in the reorganization of neuronal actin structure	multiple EGF-like-domains 10; Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May pl [...]	0.585
CORO2B	MEGF11	ENSP00000454783	ENSP00000386908	coronin, actin binding protein, 2B; May play a role in the reorganization of neuronal actin structure	multiple EGF-like-domains 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity)	0.585
CORO2B	MEGF6	ENSP00000454783	ENSP00000348982	coronin, actin binding protein, 2B; May play a role in the reorganization of neuronal actin structure	multiple EGF-like-domains 6	0.585
CORO2B	PEAR1	ENSP00000454783	ENSP00000292357	coronin, actin binding protein, 2B; May play a role in the reorganization of neuronal actin structure	platelet endothelial aggregation receptor 1; When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells (By similarity)	0.585
CUL2	KLHDC10	ENSP00000444856	ENSP00000334140	cullin 2; Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the [...]	kelch domain containing 10	0.999
CUL2	SH3GLB1	ENSP00000444856	ENSP00000418744	cullin 2; Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the [...]	SH3-domain GRB2-like endophilin B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion	0.704
KBTBD13	KLHDC10	ENSP00000388723	ENSP00000334140	kelch repeat and BTB (POZ) domain containing 13; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex	kelch domain containing 10	0.669
KLHDC10	CORO2B	ENSP00000334140	ENSP00000454783	kelch domain containing 10	coronin, actin binding protein, 2B; May play a role in the reorganization of neuronal actin structure	0.585
KLHDC10	CUL2	ENSP00000334140	ENSP00000444856	kelch domain containing 10	cullin 2; Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the [...]	0.999
KLHDC10	KBTBD13	ENSP00000334140	ENSP00000388723	kelch domain containing 10	kelch repeat and BTB (POZ) domain containing 13; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex	0.669
KLHDC10	KLHDC7A	ENSP00000334140	ENSP00000383505	kelch domain containing 10	kelch domain containing 7A	0.618
KLHDC10	MEGF10	ENSP00000334140	ENSP00000274473	kelch domain containing 10	multiple EGF-like-domains 10; Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May pl [...]	0.662
KLHDC10	MEGF11	ENSP00000334140	ENSP00000386908	kelch domain containing 10	multiple EGF-like-domains 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity)	0.612
KLHDC10	MEGF6	ENSP00000334140	ENSP00000348982	kelch domain containing 10	multiple EGF-like-domains 6	0.613
KLHDC10	PEAR1	ENSP00000334140	ENSP00000292357	kelch domain containing 10	platelet endothelial aggregation receptor 1; When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells (By similarity)	0.601
KLHDC10	SH3GLB1	ENSP00000334140	ENSP00000418744	kelch domain containing 10	SH3-domain GRB2-like endophilin B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion	0.704
KLHDC10	USP7	ENSP00000334140	ENSP00000343535	kelch domain containing 10	ubiquitin specific peptidase 7 (herpes virus-associated); Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen pero [...]	0.999
KLHDC7A	KLHDC10	ENSP00000383505	ENSP00000334140	kelch domain containing 7A	kelch domain containing 10	0.618
MEGF10	CORO2B	ENSP00000274473	ENSP00000454783	multiple EGF-like-domains 10; Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May pl [...]	coronin, actin binding protein, 2B; May play a role in the reorganization of neuronal actin structure	0.585

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