| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| D3 | DIO3 | ENSP00000427336 | ENSP00000352273 | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | deiodinase, iodothyronine, type III | 0.576 |
| D3 | FAM129B | ENSP00000427336 | ENSP00000362409 | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.720 |
| D3 | RTL1 | ENSP00000427336 | ENSP00000435342 | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | retrotransposon-like 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity) | 0.840 |
| D3 | WDR25 | ENSP00000427336 | ENSP00000334148 | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | WD repeat domain 25 | 0.495 |
| DIO3 | D3 | ENSP00000352273 | ENSP00000427336 | deiodinase, iodothyronine, type III | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | 0.576 |
| DIO3 | FAM129B | ENSP00000352273 | ENSP00000362409 | deiodinase, iodothyronine, type III | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.700 |
| DIO3 | RTL1 | ENSP00000352273 | ENSP00000435342 | deiodinase, iodothyronine, type III | retrotransposon-like 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity) | 0.821 |
| DIO3 | WDR25 | ENSP00000352273 | ENSP00000334148 | deiodinase, iodothyronine, type III | WD repeat domain 25 | 0.526 |
| FAM129B | D3 | ENSP00000362409 | ENSP00000427336 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | 0.720 |
| FAM129B | DIO3 | ENSP00000362409 | ENSP00000352273 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | deiodinase, iodothyronine, type III | 0.700 |
| FAM129B | RTL1 | ENSP00000362409 | ENSP00000435342 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | retrotransposon-like 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity) | 0.811 |
| FAM129B | WDR25 | ENSP00000362409 | ENSP00000334148 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | WD repeat domain 25 | 0.568 |
| GPR123 | WDR25 | ENSP00000376384 | ENSP00000334148 | G protein-coupled receptor 123; Orphan receptor | WD repeat domain 25 | 0.477 |
| NGDN | WDR25 | ENSP00000386134 | ENSP00000334148 | neuroguidin, EIF4E binding protein; Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (By similarity) | WD repeat domain 25 | 0.490 |
| NGDN | WDR3 | ENSP00000386134 | ENSP00000308179 | neuroguidin, EIF4E binding protein; Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (By similarity) | WD repeat domain 3 | 0.661 |
| PPP2R5C | WARS | ENSP00000412324 | ENSP00000347495 | protein phosphatase 2, regulatory subunit B’, gamma; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation | tryptophanyl-tRNA synthetase; Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression | 0.478 |
| PPP2R5C | WDR25 | ENSP00000412324 | ENSP00000334148 | protein phosphatase 2, regulatory subunit B’, gamma; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation | WD repeat domain 25 | 0.560 |
| RTL1 | D3 | ENSP00000435342 | ENSP00000427336 | retrotransposon-like 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity) | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | 0.840 |
| RTL1 | DIO3 | ENSP00000435342 | ENSP00000352273 | retrotransposon-like 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity) | deiodinase, iodothyronine, type III | 0.821 |
| RTL1 | FAM129B | ENSP00000435342 | ENSP00000362409 | retrotransposon-like 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity) | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.811 |
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