| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ERC1 | ERC2 | ENSP00000354158 | ENSP00000288221 | ELKS/RAB6-interacting/CAST family member 1 | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | 0.649 |
| ERC1 | PCLO | ENSP00000354158 | ENSP00000334319 | ELKS/RAB6-interacting/CAST family member 1 | piccolo (presynaptic cytomatrix protein) | 0.655 |
| ERC1 | RAPGEF4 | ENSP00000354158 | ENSP00000380271 | ELKS/RAB6-interacting/CAST family member 1 | Rap guanine nucleotide exchange factor (GEF) 4; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity) | 0.569 |
| ERC1 | RIMS2 | ENSP00000354158 | ENSP00000384892 | ELKS/RAB6-interacting/CAST family member 1 | regulating synaptic membrane exocytosis 2; Rab effector involved in exocytosis. May act as scaffold protein | 0.853 |
| ERC1 | UNC13A | ENSP00000354158 | ENSP00000429562 | ELKS/RAB6-interacting/CAST family member 1 | unc-13 homolog A (C. elegans); Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); [...] | 0.638 |
| ERC1 | UNC13B | ENSP00000354158 | ENSP00000367756 | ELKS/RAB6-interacting/CAST family member 1 | unc-13 homolog B (C. elegans); Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity) | 0.622 |
| ERC2 | ERC1 | ENSP00000288221 | ENSP00000354158 | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | ELKS/RAB6-interacting/CAST family member 1 | 0.649 |
| ERC2 | GIT1 | ENSP00000288221 | ENSP00000378338 | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | 0.575 |
| ERC2 | PCLO | ENSP00000288221 | ENSP00000334319 | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | piccolo (presynaptic cytomatrix protein) | 0.828 |
| ERC2 | RIMS2 | ENSP00000288221 | ENSP00000384892 | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | regulating synaptic membrane exocytosis 2; Rab effector involved in exocytosis. May act as scaffold protein | 0.858 |
| ERC2 | UNC13A | ENSP00000288221 | ENSP00000429562 | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | unc-13 homolog A (C. elegans); Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); [...] | 0.808 |
| ERC2 | UNC13B | ENSP00000288221 | ENSP00000367756 | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | unc-13 homolog B (C. elegans); Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity) | 0.445 |
| GIT1 | ERC2 | ENSP00000378338 | ENSP00000288221 | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | 0.575 |
| GIT1 | PCLO | ENSP00000378338 | ENSP00000334319 | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | piccolo (presynaptic cytomatrix protein) | 0.613 |
| PCLO | ERC1 | ENSP00000334319 | ENSP00000354158 | piccolo (presynaptic cytomatrix protein) | ELKS/RAB6-interacting/CAST family member 1 | 0.655 |
| PCLO | ERC2 | ENSP00000334319 | ENSP00000288221 | piccolo (presynaptic cytomatrix protein) | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | 0.828 |
| PCLO | GIT1 | ENSP00000334319 | ENSP00000378338 | piccolo (presynaptic cytomatrix protein) | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | 0.613 |
| PCLO | QPRT | ENSP00000334319 | ENSP00000378782 | piccolo (presynaptic cytomatrix protein) | quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA) | 0.595 |
| PCLO | RAB3A | ENSP00000334319 | ENSP00000222256 | piccolo (presynaptic cytomatrix protein) | RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal | 0.876 |
| PCLO | RABAC1 | ENSP00000334319 | ENSP00000222008 | piccolo (presynaptic cytomatrix protein) | Rab acceptor 1 (prenylated); General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity) | 0.829 |
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