node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACOT2 | HEATR4 | ENSP00000238651 | ENSP00000335447 | acyl-CoA thioesterase 2; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs | HEAT repeat containing 4 | 0.583 |
ACOT2 | PLSCR2 | ENSP00000238651 | ENSP00000420132 | acyl-CoA thioesterase 2; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs | phospholipid scramblase 2; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | 0.563 |
ACOT2 | ZNF512 | ENSP00000238651 | ENSP00000347648 | acyl-CoA thioesterase 2; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs | zinc finger protein 512; May be involved in transcriptional regulation | 0.558 |
ACOT2 | ZNF677 | ENSP00000238651 | ENSP00000334394 | acyl-CoA thioesterase 2; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs | zinc finger protein 677; May be involved in transcriptional regulation | 0.551 |
FBXL19 | ZNF512 | ENSP00000369666 | ENSP00000347648 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 512; May be involved in transcriptional regulation | 0.501 |
FBXL19 | ZNF677 | ENSP00000369666 | ENSP00000334394 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 677; May be involved in transcriptional regulation | 0.501 |
HEATR4 | ACOT2 | ENSP00000335447 | ENSP00000238651 | HEAT repeat containing 4 | acyl-CoA thioesterase 2; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs | 0.583 |
HEATR4 | PLSCR2 | ENSP00000335447 | ENSP00000420132 | HEAT repeat containing 4 | phospholipid scramblase 2; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | 0.605 |
HEATR4 | ZNF512 | ENSP00000335447 | ENSP00000347648 | HEAT repeat containing 4 | zinc finger protein 512; May be involved in transcriptional regulation | 0.685 |
HEATR4 | ZNF677 | ENSP00000335447 | ENSP00000334394 | HEAT repeat containing 4 | zinc finger protein 677; May be involved in transcriptional regulation | 0.637 |
KDM2A | ZNF512 | ENSP00000432786 | ENSP00000347648 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 512; May be involved in transcriptional regulation | 0.501 |
KDM2A | ZNF677 | ENSP00000432786 | ENSP00000334394 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 677; May be involved in transcriptional regulation | 0.501 |
KDM2B | ZNF512 | ENSP00000366271 | ENSP00000347648 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 512; May be involved in transcriptional regulation | 0.501 |
KDM2B | ZNF677 | ENSP00000366271 | ENSP00000334394 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 677; May be involved in transcriptional regulation | 0.501 |
PLSCR2 | ACOT2 | ENSP00000420132 | ENSP00000238651 | phospholipid scramblase 2; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | acyl-CoA thioesterase 2; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs | 0.563 |
PLSCR2 | HEATR4 | ENSP00000420132 | ENSP00000335447 | phospholipid scramblase 2; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | HEAT repeat containing 4 | 0.605 |
PLSCR2 | ZNF512 | ENSP00000420132 | ENSP00000347648 | phospholipid scramblase 2; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | zinc finger protein 512; May be involved in transcriptional regulation | 0.492 |
PLSCR2 | ZNF677 | ENSP00000420132 | ENSP00000334394 | phospholipid scramblase 2; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | zinc finger protein 677; May be involved in transcriptional regulation | 0.573 |
RASL11A | ZNF677 | ENSP00000241463 | ENSP00000334394 | RAS-like, family 11, member A; Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity) | zinc finger protein 677; May be involved in transcriptional regulation | 0.500 |
VN1R2 | ZNF677 | ENSP00000351244 | ENSP00000334394 | vomeronasal 1 receptor 2; Putative pheromone receptor | zinc finger protein 677; May be involved in transcriptional regulation | 0.505 |