| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CALCB | CYP2R1 | ENSP00000346017 | ENSP00000334592 | calcitonin-related polypeptide beta; CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | 0.485 |
| CALCB | PTH | ENSP00000346017 | ENSP00000282091 | calcitonin-related polypeptide beta; CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | 0.923 |
| CYP2R1 | CALCB | ENSP00000334592 | ENSP00000346017 | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | calcitonin-related polypeptide beta; CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role | 0.485 |
| CYP2R1 | DHCR7 | ENSP00000334592 | ENSP00000347717 | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) | 0.733 |
| CYP2R1 | FABP9 | ENSP00000334592 | ENSP00000368362 | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | fatty acid binding protein 9, testis | 0.816 |
| CYP2R1 | FDX1 | ENSP00000334592 | ENSP00000260270 | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | 0.589 |
| CYP2R1 | FDXR | ENSP00000334592 | ENSP00000462972 | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | ferredoxin reductase; Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver | 0.489 |
| CYP2R1 | GC | ENSP00000334592 | ENSP00000421725 | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | group-specific component (vitamin D binding protein); Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes | 0.609 |
| CYP2R1 | HNRNPCL1 | ENSP00000334592 | ENSP00000365370 | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | heterogeneous nuclear ribonucleoprotein C-like 1; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs (By similarity) | 0.824 |
| CYP2R1 | NADSYN1 | ENSP00000334592 | ENSP00000326424 | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | NAD synthetase 1 | 0.653 |
| CYP2R1 | PTH | ENSP00000334592 | ENSP00000282091 | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | 0.504 |
| CYP2R1 | VDR | ENSP00000334592 | ENSP00000447173 | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | vitamin D (1,25- dihydroxyvitamin D3) receptor; Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis | 0.700 |
| DHCR7 | CYP2R1 | ENSP00000347717 | ENSP00000334592 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | 0.733 |
| DHCR7 | NADSYN1 | ENSP00000347717 | ENSP00000326424 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) | NAD synthetase 1 | 0.507 |
| FABP9 | CYP2R1 | ENSP00000368362 | ENSP00000334592 | fatty acid binding protein 9, testis | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | 0.816 |
| FDX1 | CYP2R1 | ENSP00000260270 | ENSP00000334592 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | 0.589 |
| FDX1 | FDXR | ENSP00000260270 | ENSP00000462972 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | ferredoxin reductase; Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver | 0.999 |
| FDXR | CYP2R1 | ENSP00000462972 | ENSP00000334592 | ferredoxin reductase; Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | 0.489 |
| FDXR | FDX1 | ENSP00000462972 | ENSP00000260270 | ferredoxin reductase; Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | 0.999 |
| GC | CYP2R1 | ENSP00000421725 | ENSP00000334592 | group-specific component (vitamin D binding protein); Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes | cytochrome P450, family 2, subfamily R, polypeptide 1; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3) | 0.609 |
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