Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | LCE3C | late cornified envelope 3C; Precursors of the cornified envelope of the stratum corneum (94 aa) | ||||||||||||
Predicted Functional Partners:
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 | LCE3B | late cornified envelope 3B; Precursors of the cornified envelope of the stratum corneum (95 aa) |
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0.925 | ||||||||||
 | LCE3E | late cornified envelope 3E; Precursors of the cornified envelope of the stratum corneum (92 aa) |
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0.860 | ||||||||||
 | LCE3D | late cornified envelope 3D; Precursors of the cornified envelope of the stratum corneum (92 aa) |
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0.860 | ||||||||||
 | ELOVL6 | ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs (265 aa) |
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0.800 | ||||||||||
 | PCSK5 | proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins (1860 aa) |
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0.750 | ||||||||||
 | LCE3A | late cornified envelope 3A; Precursors of the cornified envelope of the stratum corneum (89 aa) |
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0.720 | ||||||||||
 | LCE1A | late cornified envelope 1A; Precursors of the cornified envelope of the stratum corneum (110 aa) |
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0.681 | ||||||||||
 | PGLYRP4 | peptidoglycan recognition protein 4; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity (373 aa) |
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0.610 | ||||||||||
 | PGLYRP3 | peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity (341 aa) |
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0.610 | ||||||||||
 | PRR9 | proline rich 9 (116 aa) |
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0.565 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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