RLTPR protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RLTPR

RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing (1435 aa)

Predicted Functional Partners:

NFKBIL1

0.750

DCTN4

0.662

MCF2

0.654

SESTD1

0.654

TRIO

0.654

MCF2L2

0.654

PLEKHG4B

0.654

KALRN

0.654

FADD

0.564

BAX

0.564

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAX	FADD	ENSP00000293288	ENSP00000301838	BCL2-associated X protein	Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling	0.664
BAX	RLTPR	ENSP00000293288	ENSP00000334958	BCL2-associated X protein	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.564
DCTN4	RLTPR	ENSP00000414906	ENSP00000334958	dynactin 4 (p62); Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.662
FADD	BAX	ENSP00000301838	ENSP00000293288	Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling	BCL2-associated X protein	0.664
FADD	RLTPR	ENSP00000301838	ENSP00000334958	Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.564
KALRN	MCF2	ENSP00000240874	ENSP00000430276	kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity	MCF.2 cell line derived transforming sequence	0.922
KALRN	RLTPR	ENSP00000240874	ENSP00000334958	kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.654
KALRN	TRIO	ENSP00000240874	ENSP00000339299	kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity	trio Rho guanine nucleotide exchange factor; Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth	0.900
MCF2	KALRN	ENSP00000430276	ENSP00000240874	MCF.2 cell line derived transforming sequence	kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity	0.922
MCF2	RLTPR	ENSP00000430276	ENSP00000334958	MCF.2 cell line derived transforming sequence	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.654
MCF2L2	RLTPR	ENSP00000328118	ENSP00000334958	MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity)	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.654
NFKBIL1	RLTPR	ENSP00000365318	ENSP00000334958	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.750
PLEKHG4B	RLTPR	ENSP00000283426	ENSP00000334958	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.654
RLTPR	BAX	ENSP00000334958	ENSP00000293288	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	BCL2-associated X protein	0.564
RLTPR	DCTN4	ENSP00000334958	ENSP00000414906	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	dynactin 4 (p62); Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton	0.662
RLTPR	FADD	ENSP00000334958	ENSP00000301838	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling	0.564
RLTPR	KALRN	ENSP00000334958	ENSP00000240874	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity	0.654
RLTPR	MCF2	ENSP00000334958	ENSP00000430276	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	MCF.2 cell line derived transforming sequence	0.654
RLTPR	MCF2L2	ENSP00000334958	ENSP00000328118	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity)	0.654
RLTPR	NFKBIL1	ENSP00000334958	ENSP00000365318	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	0.750

page 1 of 2

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About