node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALAD | TMPRSS6 | ENSP00000386284 | ENSP00000334962 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | transmembrane protease, serine 6 | 0.610 |
BMP6 | HAMP | ENSP00000283147 | ENSP00000222304 | bone morphogenetic protein 6; Induces cartilage and bone formation | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | 0.893 |
BMP6 | TFR2 | ENSP00000283147 | ENSP00000223051 | bone morphogenetic protein 6; Induces cartilage and bone formation | transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation | 0.648 |
BMP6 | TMPRSS6 | ENSP00000283147 | ENSP00000334962 | bone morphogenetic protein 6; Induces cartilage and bone formation | transmembrane protease, serine 6 | 0.921 |
CREB3L3 | HAMP | ENSP00000078445 | ENSP00000222304 | cAMP responsive element binding protein 3-like 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | 0.894 |
CREB3L3 | TMPRSS6 | ENSP00000078445 | ENSP00000334962 | cAMP responsive element binding protein 3-like 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression | transmembrane protease, serine 6 | 0.622 |
HAMP | BMP6 | ENSP00000222304 | ENSP00000283147 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.893 |
HAMP | CREB3L3 | ENSP00000222304 | ENSP00000078445 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | cAMP responsive element binding protein 3-like 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression | 0.894 |
HAMP | HFE | ENSP00000222304 | ENSP00000417404 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | hemochromatosis | 0.953 |
HAMP | TFR2 | ENSP00000222304 | ENSP00000223051 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation | 0.836 |
HAMP | TMPRSS6 | ENSP00000222304 | ENSP00000334962 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | transmembrane protease, serine 6 | 0.680 |
HFE | HAMP | ENSP00000417404 | ENSP00000222304 | hemochromatosis | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | 0.953 |
HFE | TFR2 | ENSP00000417404 | ENSP00000223051 | hemochromatosis | transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation | 0.994 |
HFE | TMPRSS6 | ENSP00000417404 | ENSP00000334962 | hemochromatosis | transmembrane protease, serine 6 | 0.703 |
LAMA1 | TMPRSS6 | ENSP00000374309 | ENSP00000334962 | laminin, alpha 1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | transmembrane protease, serine 6 | 0.591 |
STAT5A | STAT5B | ENSP00000341208 | ENSP00000293328 | signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation | signal transducer and activator of transcription 5B; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription | 0.956 |
STAT5A | STAT6 | ENSP00000341208 | ENSP00000300134 | signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation | signal transducer and activator of transcription 6, interleukin-4 induced; Carries out a dual function- signal transduction and activation of transcription. Involved in interleukin-4 signalling | 0.919 |
STAT5A | TMPRSS6 | ENSP00000341208 | ENSP00000334962 | signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation | transmembrane protease, serine 6 | 0.795 |
STAT5B | STAT5A | ENSP00000293328 | ENSP00000341208 | signal transducer and activator of transcription 5B; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription | signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation | 0.956 |
STAT5B | STAT6 | ENSP00000293328 | ENSP00000300134 | signal transducer and activator of transcription 5B; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription | signal transducer and activator of transcription 6, interleukin-4 induced; Carries out a dual function- signal transduction and activation of transcription. Involved in interleukin-4 signalling | 0.919 |