node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAH | HGD | ENSP00000261755 | ENSP00000283871 | fumarylacetoacetate hydrolase (fumarylacetoacetase) | homogentisate 1,2-dioxygenase | 0.896 |
FAH | HPDL | ENSP00000261755 | ENSP00000335060 | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | 0.662 |
FAH | TAT | ENSP00000261755 | ENSP00000348234 | fumarylacetoacetate hydrolase (fumarylacetoacetase) | tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine | 0.565 |
HGD | FAH | ENSP00000283871 | ENSP00000261755 | homogentisate 1,2-dioxygenase | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 0.896 |
HGD | HPDL | ENSP00000283871 | ENSP00000335060 | homogentisate 1,2-dioxygenase | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | 0.892 |
HGD | TAT | ENSP00000283871 | ENSP00000348234 | homogentisate 1,2-dioxygenase | tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine | 0.733 |
HPDL | FAH | ENSP00000335060 | ENSP00000261755 | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 0.662 |
HPDL | HGD | ENSP00000335060 | ENSP00000283871 | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | homogentisate 1,2-dioxygenase | 0.892 |
HPDL | HTRA2 | ENSP00000335060 | ENSP00000258080 | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | HtrA serine peptidase 2; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive | 0.685 |
HPDL | NUSAP1 | ENSP00000335060 | ENSP00000453403 | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | nucleolar and spindle associated protein 1 | 0.644 |
HPDL | RIF1 | ENSP00000335060 | ENSP00000243326 | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | RAP1 interacting factor homolog (yeast) | 0.862 |
HPDL | STMN1 | ENSP00000335060 | ENSP00000410452 | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | stathmin 1; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity) | 0.644 |
HPDL | TAT | ENSP00000335060 | ENSP00000348234 | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine | 0.690 |
HPDL | TCOF1 | ENSP00000335060 | ENSP00000421655 | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | Treacher Collins-Franceschetti syndrome 1; May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early embryonic development, particularly in development of the craniofacial complex (By similarity). May participate in certain stages of ribosome biogenesis | 0.644 |
HPDL | TOR1AIP1 | ENSP00000335060 | ENSP00000393292 | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | torsin A interacting protein 1 | 0.644 |
HPDL | TST | ENSP00000335060 | ENSP00000249042 | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | thiosulfate sulfurtransferase (rhodanese); Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA | 0.657 |
HTRA2 | HPDL | ENSP00000258080 | ENSP00000335060 | HtrA serine peptidase 2; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | 0.685 |
NUSAP1 | HPDL | ENSP00000453403 | ENSP00000335060 | nucleolar and spindle associated protein 1 | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | 0.644 |
RIF1 | HPDL | ENSP00000243326 | ENSP00000335060 | RAP1 interacting factor homolog (yeast) | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | 0.862 |
RIF1 | TOR1AIP1 | ENSP00000243326 | ENSP00000393292 | RAP1 interacting factor homolog (yeast) | torsin A interacting protein 1 | 0.904 |