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TCOF1 TCOF1 STMN1 STMN1 NUSAP1 NUSAP1 TAT TAT HPDL HPDL TOR1AIP1 TOR1AIP1 HGD HGD FAH FAH RIF1 RIF1 HTRA2 HTRA2 TST TST
"HPDL" - 4-hydroxyphenylpyruvate dioxygenase-like in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
HPDL4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) (371 aa)    
Predicted Functional Partners:
HGD
homogentisate 1,2-dioxygenase (445 aa)
score_image     score_image     score_image   0.892
RIF1
RAP1 interacting factor homolog (yeast) (2472 aa)
        score_image       0.862
TAT
tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine (454 aa)
      score_image     score_image   0.690
HTRA2
HtrA serine peptidase 2; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive (458 aa)
        score_image   score_image   0.685
FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase) (419 aa)
score_image   score_image score_image     score_image   0.662
TST
thiosulfate sulfurtransferase (rhodanese); Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (297 aa)
        score_image   score_image   0.657
NUSAP1
nucleolar and spindle associated protein 1 (441 aa)
        score_image       0.644
TCOF1
Treacher Collins-Franceschetti syndrome 1; May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early embryonic development, particularly in development of the craniofacial complex (By similarity). May participate in certain stages of ribosome biogenesis (1488 aa)
        score_image       0.644
STMN1
stathmin 1; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity) (174 aa)
        score_image       0.644
TOR1AIP1
torsin A interacting protein 1 (583 aa)
        score_image       0.644
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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