| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD274 | CD3D | ENSP00000370989 | ENSP00000300692 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.900 |
| CD274 | CD3E | ENSP00000370989 | ENSP00000354566 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.900 |
| CD274 | CD3G | ENSP00000370989 | ENSP00000431445 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.900 |
| CD274 | CD8A | ENSP00000370989 | ENSP00000283635 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | 0.720 |
| CD274 | CSK | ENSP00000370989 | ENSP00000220003 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | c-src tyrosine kinase; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter p [...] | 0.900 |
| CD274 | HLA-DRB1 | ENSP00000370989 | ENSP00000353099 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | major histocompatibility complex, class II, DR beta 1 | 0.900 |
| CD274 | LCK | ENSP00000370989 | ENSP00000337825 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | lymphocyte-specific protein tyrosine kinase | 0.911 |
| CD274 | PDCD1 | ENSP00000370989 | ENSP00000335062 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | programmed cell death 1; Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors | 0.999 |
| CD274 | PDCD1LG2 | ENSP00000370989 | ENSP00000380855 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | programmed cell death 1 ligand 2; Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity) | 0.914 |
| CD274 | PTPN11 | ENSP00000370989 | ENSP00000340944 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.968 |
| CD3D | CD274 | ENSP00000300692 | ENSP00000370989 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | 0.900 |
| CD3D | CD3E | ENSP00000300692 | ENSP00000354566 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.999 |
| CD3D | CD3G | ENSP00000300692 | ENSP00000431445 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.965 |
| CD3D | CD8A | ENSP00000300692 | ENSP00000283635 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | 0.975 |
| CD3D | CSK | ENSP00000300692 | ENSP00000220003 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | c-src tyrosine kinase; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter p [...] | 0.900 |
| CD3D | HLA-DRB1 | ENSP00000300692 | ENSP00000353099 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | major histocompatibility complex, class II, DR beta 1 | 0.903 |
| CD3D | LCK | ENSP00000300692 | ENSP00000337825 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | lymphocyte-specific protein tyrosine kinase | 0.924 |
| CD3D | PDCD1 | ENSP00000300692 | ENSP00000335062 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | programmed cell death 1; Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors | 0.901 |
| CD3D | PDCD1LG2 | ENSP00000300692 | ENSP00000380855 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | programmed cell death 1 ligand 2; Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity) | 0.900 |
| CD3D | PTPN11 | ENSP00000300692 | ENSP00000340944 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.900 |
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