node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHSY3 | GPR144 | ENSP00000302629 | ENSP00000335156 | chondroitin sulfate synthase 3; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1 | G protein-coupled receptor 144; Orphan receptor | 0.527 |
CLCN7 | GPR144 | ENSP00000372193 | ENSP00000335156 | chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen | G protein-coupled receptor 144; Orphan receptor | 0.478 |
CLCN7 | TELO2 | ENSP00000372193 | ENSP00000262319 | chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen | TEL2, telomere maintenance 2, homolog (S. cerevisiae); Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complex [...] | 0.612 |
CLCN7 | VEPH1 | ENSP00000372193 | ENSP00000354919 | chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen | ventricular zone expressed PH domain homolog 1 (zebrafish) | 0.617 |
GPR114 | GPR123 | ENSP00000290823 | ENSP00000376384 | G protein-coupled receptor 114; Orphan receptor | G protein-coupled receptor 123; Orphan receptor | 0.626 |
GPR114 | GPR125 | ENSP00000290823 | ENSP00000334952 | G protein-coupled receptor 114; Orphan receptor | G protein-coupled receptor 125; Orphan receptor | 0.516 |
GPR114 | GPR144 | ENSP00000290823 | ENSP00000335156 | G protein-coupled receptor 114; Orphan receptor | G protein-coupled receptor 144; Orphan receptor | 0.530 |
GPR123 | GPR114 | ENSP00000376384 | ENSP00000290823 | G protein-coupled receptor 123; Orphan receptor | G protein-coupled receptor 114; Orphan receptor | 0.626 |
GPR123 | GPR144 | ENSP00000376384 | ENSP00000335156 | G protein-coupled receptor 123; Orphan receptor | G protein-coupled receptor 144; Orphan receptor | 0.700 |
GPR125 | GPR114 | ENSP00000334952 | ENSP00000290823 | G protein-coupled receptor 125; Orphan receptor | G protein-coupled receptor 114; Orphan receptor | 0.516 |
GPR125 | GPR144 | ENSP00000334952 | ENSP00000335156 | G protein-coupled receptor 125; Orphan receptor | G protein-coupled receptor 144; Orphan receptor | 0.599 |
GPR144 | CHSY3 | ENSP00000335156 | ENSP00000302629 | G protein-coupled receptor 144; Orphan receptor | chondroitin sulfate synthase 3; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1 | 0.527 |
GPR144 | CLCN7 | ENSP00000335156 | ENSP00000372193 | G protein-coupled receptor 144; Orphan receptor | chloride channel, voltage-sensitive 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen | 0.478 |
GPR144 | GPR114 | ENSP00000335156 | ENSP00000290823 | G protein-coupled receptor 144; Orphan receptor | G protein-coupled receptor 114; Orphan receptor | 0.530 |
GPR144 | GPR123 | ENSP00000335156 | ENSP00000376384 | G protein-coupled receptor 144; Orphan receptor | G protein-coupled receptor 123; Orphan receptor | 0.700 |
GPR144 | GPR125 | ENSP00000335156 | ENSP00000334952 | G protein-coupled receptor 144; Orphan receptor | G protein-coupled receptor 125; Orphan receptor | 0.599 |
GPR144 | GPR149 | ENSP00000335156 | ENSP00000374390 | G protein-coupled receptor 144; Orphan receptor | G protein-coupled receptor 149; Orphan receptor | 0.461 |
GPR144 | NR6A1 | ENSP00000335156 | ENSP00000420267 | G protein-coupled receptor 144; Orphan receptor | nuclear receptor subfamily 6, group A, member 1; Orphan nuclear receptor. Binds to a response element containing the sequence 5’-TCAAGGTCA-3’. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity) | 0.677 |
GPR144 | PSMB7 | ENSP00000335156 | ENSP00000259457 | G protein-coupled receptor 144; Orphan receptor | proteasome (prosome, macropain) subunit, beta type, 7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity | 0.565 |
GPR144 | TELO2 | ENSP00000335156 | ENSP00000262319 | G protein-coupled receptor 144; Orphan receptor | TEL2, telomere maintenance 2, homolog (S. cerevisiae); Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complex [...] | 0.501 |