node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH18A1 | ALDH9A1 | ENSP00000360268 | ENSP00000346827 | aldehyde dehydrogenase 18 family, member A1 | aldehyde dehydrogenase 9 family, member A1; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction | 0.643 |
ALDH18A1 | APIP | ENSP00000360268 | ENSP00000379133 | aldehyde dehydrogenase 18 family, member A1 | APAF1 interacting protein; Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death (By similarity) | 0.579 |
ALDH18A1 | CCDC94 | ENSP00000360268 | ENSP00000262962 | aldehyde dehydrogenase 18 family, member A1 | coiled-coil domain containing 94 | 0.604 |
ALDH18A1 | FBXO22 | ENSP00000360268 | ENSP00000307833 | aldehyde dehydrogenase 18 family, member A1 | F-box protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function | 0.634 |
ALDH18A1 | PPP6R1 | ENSP00000360268 | ENSP00000414202 | aldehyde dehydrogenase 18 family, member A1 | protein phosphatase 6, regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha | 0.519 |
ALDH18A1 | PPP6R2 | ENSP00000360268 | ENSP00000379090 | aldehyde dehydrogenase 18 family, member A1 | protein phosphatase 6, regulatory subunit 2; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha | 0.529 |
ALDH18A1 | TMLHE | ENSP00000360268 | ENSP00000335261 | aldehyde dehydrogenase 18 family, member A1 | trimethyllysine hydroxylase, epsilon; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) | 0.644 |
ALDH9A1 | ALDH18A1 | ENSP00000346827 | ENSP00000360268 | aldehyde dehydrogenase 9 family, member A1; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction | aldehyde dehydrogenase 18 family, member A1 | 0.643 |
ALDH9A1 | TMLHE | ENSP00000346827 | ENSP00000335261 | aldehyde dehydrogenase 9 family, member A1; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction | trimethyllysine hydroxylase, epsilon; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) | 0.570 |
APIP | ALDH18A1 | ENSP00000379133 | ENSP00000360268 | APAF1 interacting protein; Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death (By similarity) | aldehyde dehydrogenase 18 family, member A1 | 0.579 |
APIP | CCDC94 | ENSP00000379133 | ENSP00000262962 | APAF1 interacting protein; Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death (By similarity) | coiled-coil domain containing 94 | 0.510 |
APIP | FBXO22 | ENSP00000379133 | ENSP00000307833 | APAF1 interacting protein; Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death (By similarity) | F-box protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function | 0.477 |
APIP | PPP6R1 | ENSP00000379133 | ENSP00000414202 | APAF1 interacting protein; Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death (By similarity) | protein phosphatase 6, regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha | 0.434 |
APIP | PPP6R2 | ENSP00000379133 | ENSP00000379090 | APAF1 interacting protein; Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death (By similarity) | protein phosphatase 6, regulatory subunit 2; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha | 0.465 |
APIP | TMLHE | ENSP00000379133 | ENSP00000335261 | APAF1 interacting protein; Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death (By similarity) | trimethyllysine hydroxylase, epsilon; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) | 0.487 |
CCDC94 | ALDH18A1 | ENSP00000262962 | ENSP00000360268 | coiled-coil domain containing 94 | aldehyde dehydrogenase 18 family, member A1 | 0.604 |
CCDC94 | APIP | ENSP00000262962 | ENSP00000379133 | coiled-coil domain containing 94 | APAF1 interacting protein; Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death (By similarity) | 0.510 |
CCDC94 | FBXO22 | ENSP00000262962 | ENSP00000307833 | coiled-coil domain containing 94 | F-box protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function | 0.581 |
CCDC94 | PPP6R1 | ENSP00000262962 | ENSP00000414202 | coiled-coil domain containing 94 | protein phosphatase 6, regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha | 0.520 |
CCDC94 | PPP6R2 | ENSP00000262962 | ENSP00000379090 | coiled-coil domain containing 94 | protein phosphatase 6, regulatory subunit 2; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha | 0.537 |