FOXD2 protein (Homo sapiens) - STRING network view

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Score

FOXD2

forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity) (495 aa)

Predicted Functional Partners:

PAX6

0.729

SOX10

0.695

SOX9

0.695

MDK

0.690

MYF5

0.678

TBX19

0.643

T

0.643

PAX7

0.637

PAX3

0.634

POU5F1

0.627

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FOXD2	MDK	ENSP00000335493	ENSP00000352852	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	midkine (neurite growth-promoting factor 2); Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By [...]	0.690
FOXD2	MYF5	ENSP00000335493	ENSP00000228644	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	myogenic factor 5; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein	0.678
FOXD2	PAX3	ENSP00000335493	ENSP00000375921	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	paired box 3	0.634
FOXD2	PAX6	ENSP00000335493	ENSP00000368401	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes	0.729
FOXD2	PAX7	ENSP00000335493	ENSP00000364524	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	paired box 7; Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation (By similarity)	0.637
FOXD2	POU5F1	ENSP00000335493	ENSP00000259915	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	POU class 5 homeobox 1	0.627
FOXD2	SOX10	ENSP00000335493	ENSP00000354130	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	SRY (sex determining region Y)-box 10; Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity)	0.695
FOXD2	SOX9	ENSP00000335493	ENSP00000245479	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	SRY (sex determining region Y)-box 9; Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes	0.695
FOXD2	T	ENSP00000335493	ENSP00000296946	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	T, brachyury homolog (mouse); Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site	0.643
FOXD2	TBX19	ENSP00000335493	ENSP00000356795	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	T-box 19; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters	0.643
MDK	FOXD2	ENSP00000352852	ENSP00000335493	midkine (neurite growth-promoting factor 2); Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By [...]	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	0.690
MYF5	FOXD2	ENSP00000228644	ENSP00000335493	myogenic factor 5; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	0.678
MYF5	PAX3	ENSP00000228644	ENSP00000375921	myogenic factor 5; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein	paired box 3	0.967
MYF5	PAX6	ENSP00000228644	ENSP00000368401	myogenic factor 5; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein	paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes	0.422
MYF5	PAX7	ENSP00000228644	ENSP00000364524	myogenic factor 5; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein	paired box 7; Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation (By similarity)	0.976
MYF5	T	ENSP00000228644	ENSP00000296946	myogenic factor 5; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein	T, brachyury homolog (mouse); Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site	0.623
MYF5	TBX19	ENSP00000228644	ENSP00000356795	myogenic factor 5; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein	T-box 19; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters	0.623
PAX3	FOXD2	ENSP00000375921	ENSP00000335493	paired box 3	forkhead box D2; Probable transcription factor involved in embryogenesis and somatogenesis (By similarity)	0.634
PAX3	MYF5	ENSP00000375921	ENSP00000228644	paired box 3	myogenic factor 5; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein	0.967
PAX3	POU5F1	ENSP00000375921	ENSP00000259915	paired box 3	POU class 5 homeobox 1	0.704

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