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STRINGSTRING
GRK5 GRK5 GRP GRP NPS NPS CCK CCK CCKBR CCKBR OXT OXT GCG GCG NTS NTS TAC1 TAC1 CCKAR CCKAR GAST GAST
"CCKBR" - cholecystokinin B receptor in Homo sapiens
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CCKBRcholecystokinin B receptor; Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (447 aa)    
Predicted Functional Partners:
CCK
cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion (115 aa)
        score_image score_image score_image   0.999
GAST
gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine (101 aa)
            score_image   0.980
GRP
gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity) (148 aa)
          score_image score_image   0.964
CCKAR
cholecystokinin A receptor; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (428 aa)
        score_image score_image score_image score_image 0.958
NPS
neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) (89 aa)
          score_image score_image   0.956
NTS
neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle (170 aa)
          score_image score_image   0.955
GRK5
G protein-coupled receptor kinase 5; Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein- coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates- Hsc70- in [...] (590 aa)
          score_image score_image   0.945
TAC1
tachykinin, precursor 1 (129 aa)
          score_image score_image   0.944
GCG
glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life (180 aa)
          score_image score_image   0.938
OXT
oxytocin/neurophysin I prepropeptide; Neurophysin 1 specifically binds oxytocin (125 aa)
          score_image score_image   0.938
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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