SPATA21 protein (Homo sapiens) - STRING network view

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SPATA21

spermatogenesis associated 21; Involved in the differentiation of haploid spermatids (By similarity) (469 aa)

Predicted Functional Partners:

MYO5A

0.700

MYO5B

0.700

MYO5C

0.700

OBSCN

0.679

MYO1G

0.658

CETN1

0.647

CETN3

0.635

CAPN13

0.635

POTEE

0.628

POTEI

0.628

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAPN13	SPATA21	ENSP00000295055	ENSP00000335612	calpain 13; Probable non-lysosomal thiol-protease (By similarity)	spermatogenesis associated 21; Involved in the differentiation of haploid spermatids (By similarity)	0.635
CETN1	POTEE	ENSP00000319052	ENSP00000439189	centrin, EF-hand protein, 1; Plays a fundamental role in microtubule-organizing center structure and function	POTE ankyrin domain family member E	0.541
CETN1	POTEI	ENSP00000319052	ENSP00000392718	centrin, EF-hand protein, 1; Plays a fundamental role in microtubule-organizing center structure and function	POTE ankyrin domain family, member I	0.541
CETN1	SPATA21	ENSP00000319052	ENSP00000335612	centrin, EF-hand protein, 1; Plays a fundamental role in microtubule-organizing center structure and function	spermatogenesis associated 21; Involved in the differentiation of haploid spermatids (By similarity)	0.647
CETN3	POTEE	ENSP00000283122	ENSP00000439189	centrin, EF-hand protein, 3; Plays a fundamental role in microtubule-organizing center structure and function	POTE ankyrin domain family member E	0.541
CETN3	POTEI	ENSP00000283122	ENSP00000392718	centrin, EF-hand protein, 3; Plays a fundamental role in microtubule-organizing center structure and function	POTE ankyrin domain family, member I	0.541
CETN3	SPATA21	ENSP00000283122	ENSP00000335612	centrin, EF-hand protein, 3; Plays a fundamental role in microtubule-organizing center structure and function	spermatogenesis associated 21; Involved in the differentiation of haploid spermatids (By similarity)	0.635
MYO1G	OBSCN	ENSP00000258787	ENSP00000455507	myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.562
MYO1G	POTEE	ENSP00000258787	ENSP00000439189	myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)	POTE ankyrin domain family member E	0.724
MYO1G	POTEI	ENSP00000258787	ENSP00000392718	myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)	POTE ankyrin domain family, member I	0.724
MYO1G	SPATA21	ENSP00000258787	ENSP00000335612	myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)	spermatogenesis associated 21; Involved in the differentiation of haploid spermatids (By similarity)	0.658
MYO5A	OBSCN	ENSP00000382177	ENSP00000455507	myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.631
MYO5A	POTEE	ENSP00000382177	ENSP00000439189	myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation	POTE ankyrin domain family member E	0.750
MYO5A	POTEI	ENSP00000382177	ENSP00000392718	myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation	POTE ankyrin domain family, member I	0.750
MYO5A	SPATA21	ENSP00000382177	ENSP00000335612	myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation	spermatogenesis associated 21; Involved in the differentiation of haploid spermatids (By similarity)	0.700
MYO5B	OBSCN	ENSP00000285039	ENSP00000455507	myosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity)	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.659
MYO5B	POTEE	ENSP00000285039	ENSP00000439189	myosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity)	POTE ankyrin domain family member E	0.750
MYO5B	POTEI	ENSP00000285039	ENSP00000392718	myosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity)	POTE ankyrin domain family, member I	0.750
MYO5B	SPATA21	ENSP00000285039	ENSP00000335612	myosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity)	spermatogenesis associated 21; Involved in the differentiation of haploid spermatids (By similarity)	0.700
MYO5C	OBSCN	ENSP00000261839	ENSP00000455507	myosin VC; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.651

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