| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FMN2 | FMNL3 | ENSP00000318884 | ENSP00000335655 | formin 2; Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CD [...] | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | 0.590 |
| FMNL3 | FMN2 | ENSP00000335655 | ENSP00000318884 | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | formin 2; Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CD [...] | 0.590 |
| FMNL3 | FNBP4 | ENSP00000335655 | ENSP00000263773 | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | formin binding protein 4 | 0.518 |
| FMNL3 | PBX1 | ENSP00000335655 | ENSP00000405890 | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | pre-B-cell leukemia homeobox 1; Binds the sequence 5’-ATCAATCAA-3’. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] | 0.477 |
| FMNL3 | PBX2 | ENSP00000335655 | ENSP00000364190 | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | pre-B-cell leukemia homeobox 2; Transcriptional activator that binds the sequence 5’- ATCAATCAA-3’. Activates transcription of PF4 in complex with MEIS1 | 0.457 |
| FMNL3 | PRPF40A | ENSP00000335655 | ENSP00000386458 | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae); Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing | 0.740 |
| FMNL3 | SCAF8 | ENSP00000335655 | ENSP00000356146 | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | SR-related CTD-associated factor 8; May play a role in mRNA processing | 0.472 |
| FMNL3 | SRGAP2 | ENSP00000335655 | ENSP00000295713 | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | SLIT-ROBO Rho GTPase activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | 0.895 |
| FMNL3 | SRGAP3 | ENSP00000335655 | ENSP00000373347 | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | SLIT-ROBO Rho GTPase activating protein 3; GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons | 0.866 |
| FMNL3 | UAP1 | ENSP00000335655 | ENSP00000356903 | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | UDP-N-acteylglucosamine pyrophosphorylase 1; Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P | 0.514 |
| FMNL3 | UBC | ENSP00000335655 | ENSP00000344818 | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | ubiquitin C | 0.483 |
| FNBP4 | FMNL3 | ENSP00000263773 | ENSP00000335655 | formin binding protein 4 | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | 0.518 |
| FNBP4 | PRPF40A | ENSP00000263773 | ENSP00000386458 | formin binding protein 4 | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae); Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing | 0.446 |
| PBX1 | FMNL3 | ENSP00000405890 | ENSP00000335655 | pre-B-cell leukemia homeobox 1; Binds the sequence 5’-ATCAATCAA-3’. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | 0.477 |
| PBX1 | PBX2 | ENSP00000405890 | ENSP00000364190 | pre-B-cell leukemia homeobox 1; Binds the sequence 5’-ATCAATCAA-3’. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] | pre-B-cell leukemia homeobox 2; Transcriptional activator that binds the sequence 5’- ATCAATCAA-3’. Activates transcription of PF4 in complex with MEIS1 | 0.582 |
| PBX1 | UBC | ENSP00000405890 | ENSP00000344818 | pre-B-cell leukemia homeobox 1; Binds the sequence 5’-ATCAATCAA-3’. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] | ubiquitin C | 0.575 |
| PBX2 | FMNL3 | ENSP00000364190 | ENSP00000335655 | pre-B-cell leukemia homeobox 2; Transcriptional activator that binds the sequence 5’- ATCAATCAA-3’. Activates transcription of PF4 in complex with MEIS1 | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | 0.457 |
| PBX2 | PBX1 | ENSP00000364190 | ENSP00000405890 | pre-B-cell leukemia homeobox 2; Transcriptional activator that binds the sequence 5’- ATCAATCAA-3’. Activates transcription of PF4 in complex with MEIS1 | pre-B-cell leukemia homeobox 1; Binds the sequence 5’-ATCAATCAA-3’. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] | 0.582 |
| PRPF40A | FMNL3 | ENSP00000386458 | ENSP00000335655 | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae); Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing | formin-like 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration | 0.740 |
| PRPF40A | FNBP4 | ENSP00000386458 | ENSP00000263773 | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae); Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing | formin binding protein 4 | 0.446 |
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