node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP13A2 | FAM192A | ENSP00000327214 | ENSP00000335808 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | family with sequence similarity 192, member A | 0.418 |
ATP13A2 | UBC | ENSP00000327214 | ENSP00000344818 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | ubiquitin C | 0.890 |
CLK3 | FAM192A | ENSP00000378505 | ENSP00000335808 | CDC-like kinase 3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells | family with sequence similarity 192, member A | 0.558 |
CLK3 | UBC | ENSP00000378505 | ENSP00000344818 | CDC-like kinase 3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells | ubiquitin C | 0.581 |
FAM192A | ATP13A2 | ENSP00000335808 | ENSP00000327214 | family with sequence similarity 192, member A | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | 0.418 |
FAM192A | CLK3 | ENSP00000335808 | ENSP00000378505 | family with sequence similarity 192, member A | CDC-like kinase 3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells | 0.558 |
FAM192A | RSPRY1 | ENSP00000335808 | ENSP00000377942 | family with sequence similarity 192, member A | ring finger and SPRY domain containing 1 | 0.714 |
FAM192A | SLC6A14 | ENSP00000335808 | ENSP00000360967 | family with sequence similarity 192, member A | solute carrier family 6 (amino acid transporter), member 14; Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner | 0.442 |
FAM192A | SUMO2 | ENSP00000335808 | ENSP00000405965 | family with sequence similarity 192, member A | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.520 |
FAM192A | UBC | ENSP00000335808 | ENSP00000344818 | family with sequence similarity 192, member A | ubiquitin C | 0.723 |
RSPRY1 | FAM192A | ENSP00000377942 | ENSP00000335808 | ring finger and SPRY domain containing 1 | family with sequence similarity 192, member A | 0.714 |
RSPRY1 | UBC | ENSP00000377942 | ENSP00000344818 | ring finger and SPRY domain containing 1 | ubiquitin C | 0.721 |
SLC6A14 | FAM192A | ENSP00000360967 | ENSP00000335808 | solute carrier family 6 (amino acid transporter), member 14; Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner | family with sequence similarity 192, member A | 0.442 |
SUMO2 | FAM192A | ENSP00000405965 | ENSP00000335808 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | family with sequence similarity 192, member A | 0.520 |
SUMO2 | UBC | ENSP00000405965 | ENSP00000344818 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | ubiquitin C | 0.999 |
UBC | ATP13A2 | ENSP00000344818 | ENSP00000327214 | ubiquitin C | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | 0.890 |
UBC | CLK3 | ENSP00000344818 | ENSP00000378505 | ubiquitin C | CDC-like kinase 3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells | 0.581 |
UBC | FAM192A | ENSP00000344818 | ENSP00000335808 | ubiquitin C | family with sequence similarity 192, member A | 0.723 |
UBC | RSPRY1 | ENSP00000344818 | ENSP00000377942 | ubiquitin C | ring finger and SPRY domain containing 1 | 0.721 |
UBC | SUMO2 | ENSP00000344818 | ENSP00000405965 | ubiquitin C | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.999 |