node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY1 | ADCY2 | ENSP00000297323 | ENSP00000342952 | adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning | adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase | 0.962 |
ADCY1 | ADCY5 | ENSP00000297323 | ENSP00000419361 | adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 0.908 |
ADCY1 | ADCY9 | ENSP00000297323 | ENSP00000294016 | adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | 0.928 |
ADCY1 | ADORA2A | ENSP00000297323 | ENSP00000336630 | adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning | adenosine A2a receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.919 |
ADCY1 | NPS | ENSP00000297323 | ENSP00000381105 | adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.900 |
ADCY1 | POMC | ENSP00000297323 | ENSP00000264708 | adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.913 |
ADCY1 | VIP | ENSP00000297323 | ENSP00000356213 | adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning | vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder | 0.903 |
ADCY1 | VIPR1 | ENSP00000297323 | ENSP00000327246 | adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning | vasoactive intestinal peptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38 | 0.902 |
ADCY2 | ADCY1 | ENSP00000342952 | ENSP00000297323 | adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase | adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning | 0.962 |
ADCY2 | ADCY5 | ENSP00000342952 | ENSP00000419361 | adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 0.964 |
ADCY2 | ADCY9 | ENSP00000342952 | ENSP00000294016 | adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | 0.931 |
ADCY2 | ADORA2A | ENSP00000342952 | ENSP00000336630 | adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase | adenosine A2a receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.920 |
ADCY2 | NPS | ENSP00000342952 | ENSP00000381105 | adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.904 |
ADCY2 | POMC | ENSP00000342952 | ENSP00000264708 | adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.908 |
ADCY2 | VIP | ENSP00000342952 | ENSP00000356213 | adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase | vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder | 0.904 |
ADCY2 | VIPR1 | ENSP00000342952 | ENSP00000327246 | adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase | vasoactive intestinal peptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38 | 0.900 |
ADCY5 | ADCY1 | ENSP00000419361 | ENSP00000297323 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning | 0.908 |
ADCY5 | ADCY2 | ENSP00000419361 | ENSP00000342952 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase | 0.964 |
ADCY5 | ADCY9 | ENSP00000419361 | ENSP00000294016 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | 0.934 |
ADCY5 | ADORA2A | ENSP00000419361 | ENSP00000336630 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | adenosine A2a receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.923 |