TBC1D22A protein (Homo sapiens) - STRING network view

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TBC1D22A

TBC1 domain family, member 22A (517 aa)

Predicted Functional Partners:

RAB1B

0.842

RAB1A

0.827

RAB7A

0.805

DDHD2

0.761

SEC23IP

0.761

DDHD1

0.761

RAB43

0.734

COG6

0.725

SYS1

0.725

RABL6

0.723

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COG6	RAB1A	ENSP00000397441	ENSP00000387286	component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity)	RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity	0.492
COG6	RAB1B	ENSP00000397441	ENSP00000310226	component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity)	RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments	0.426
COG6	SYS1	ENSP00000397441	ENSP00000243918	component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity)	SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae); Involved in protein trafficking. May serve as a receptor for ARFRP1	0.874
COG6	TBC1D22A	ENSP00000397441	ENSP00000336724	component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity)	TBC1 domain family, member 22A	0.725
DDHD1	TBC1D22A	ENSP00000327104	ENSP00000336724	DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity	TBC1 domain family, member 22A	0.761
DDHD2	TBC1D22A	ENSP00000380352	ENSP00000336724	DDHD domain containing 2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane	TBC1 domain family, member 22A	0.761
RAB1A	COG6	ENSP00000387286	ENSP00000397441	RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity	component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity)	0.492
RAB1A	RAB7A	ENSP00000387286	ENSP00000265062	RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity	RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...]	0.972
RAB1A	TBC1D22A	ENSP00000387286	ENSP00000336724	RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity	TBC1 domain family, member 22A	0.827
RAB1B	COG6	ENSP00000310226	ENSP00000397441	RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments	component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity)	0.426
RAB1B	TBC1D22A	ENSP00000310226	ENSP00000336724	RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments	TBC1 domain family, member 22A	0.842
RAB43	TBC1D22A	ENSP00000319781	ENSP00000336724	RAB43, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport o [...]	TBC1 domain family, member 22A	0.734
RAB7A	RAB1A	ENSP00000265062	ENSP00000387286	RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...]	RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity	0.972
RAB7A	RABL6	ENSP00000265062	ENSP00000360727	RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...]	RAB, member RAS oncogene family-like 6	0.584
RAB7A	TBC1D22A	ENSP00000265062	ENSP00000336724	RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...]	TBC1 domain family, member 22A	0.805
RABL6	RAB7A	ENSP00000360727	ENSP00000265062	RAB, member RAS oncogene family-like 6	RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...]	0.584
RABL6	TBC1D22A	ENSP00000360727	ENSP00000336724	RAB, member RAS oncogene family-like 6	TBC1 domain family, member 22A	0.723
SEC23IP	TBC1D22A	ENSP00000358071	ENSP00000336724	SEC23 interacting protein; Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P)	TBC1 domain family, member 22A	0.761
SYS1	COG6	ENSP00000243918	ENSP00000397441	SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae); Involved in protein trafficking. May serve as a receptor for ARFRP1	component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity)	0.874
SYS1	TBC1D22A	ENSP00000243918	ENSP00000336724	SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae); Involved in protein trafficking. May serve as a receptor for ARFRP1	TBC1 domain family, member 22A	0.725

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