node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COG6 | RAB1A | ENSP00000397441 | ENSP00000387286 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | 0.492 |
COG6 | RAB1B | ENSP00000397441 | ENSP00000310226 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments | 0.426 |
COG6 | SYS1 | ENSP00000397441 | ENSP00000243918 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae); Involved in protein trafficking. May serve as a receptor for ARFRP1 | 0.874 |
COG6 | TBC1D22A | ENSP00000397441 | ENSP00000336724 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | TBC1 domain family, member 22A | 0.725 |
DDHD1 | TBC1D22A | ENSP00000327104 | ENSP00000336724 | DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity | TBC1 domain family, member 22A | 0.761 |
DDHD2 | TBC1D22A | ENSP00000380352 | ENSP00000336724 | DDHD domain containing 2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane | TBC1 domain family, member 22A | 0.761 |
RAB1A | COG6 | ENSP00000387286 | ENSP00000397441 | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | 0.492 |
RAB1A | RAB7A | ENSP00000387286 | ENSP00000265062 | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | 0.972 |
RAB1A | TBC1D22A | ENSP00000387286 | ENSP00000336724 | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | TBC1 domain family, member 22A | 0.827 |
RAB1B | COG6 | ENSP00000310226 | ENSP00000397441 | RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | 0.426 |
RAB1B | TBC1D22A | ENSP00000310226 | ENSP00000336724 | RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments | TBC1 domain family, member 22A | 0.842 |
RAB43 | TBC1D22A | ENSP00000319781 | ENSP00000336724 | RAB43, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport o [...] | TBC1 domain family, member 22A | 0.734 |
RAB7A | RAB1A | ENSP00000265062 | ENSP00000387286 | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity | 0.972 |
RAB7A | RABL6 | ENSP00000265062 | ENSP00000360727 | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | RAB, member RAS oncogene family-like 6 | 0.584 |
RAB7A | TBC1D22A | ENSP00000265062 | ENSP00000336724 | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | TBC1 domain family, member 22A | 0.805 |
RABL6 | RAB7A | ENSP00000360727 | ENSP00000265062 | RAB, member RAS oncogene family-like 6 | RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in [...] | 0.584 |
RABL6 | TBC1D22A | ENSP00000360727 | ENSP00000336724 | RAB, member RAS oncogene family-like 6 | TBC1 domain family, member 22A | 0.723 |
SEC23IP | TBC1D22A | ENSP00000358071 | ENSP00000336724 | SEC23 interacting protein; Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P) | TBC1 domain family, member 22A | 0.761 |
SYS1 | COG6 | ENSP00000243918 | ENSP00000397441 | SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae); Involved in protein trafficking. May serve as a receptor for ARFRP1 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | 0.874 |
SYS1 | TBC1D22A | ENSP00000243918 | ENSP00000336724 | SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae); Involved in protein trafficking. May serve as a receptor for ARFRP1 | TBC1 domain family, member 22A | 0.725 |