OPRL1 protein (Homo sapiens) - STRING network view

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OPRL1

opiate receptor-like 1; Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (370 aa)

Predicted Functional Partners:

PNOC

0.998

PENK

0.974

RGS19

0.963

PDYN

0.954

CNR1

0.933

SST

0.930

POMC

0.927

NPY

0.925

KNG1

0.922

GAL

0.918

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNR1	GAL	ENSP00000358511	ENSP00000265643	cannabinoid receptor 1 (brain)	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	0.931
CNR1	KNG1	ENSP00000358511	ENSP00000265023	cannabinoid receptor 1 (brain)	kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...]	0.948
CNR1	NPY	ENSP00000358511	ENSP00000242152	cannabinoid receptor 1 (brain)	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	0.956
CNR1	OPRL1	ENSP00000358511	ENSP00000336764	cannabinoid receptor 1 (brain)	opiate receptor-like 1; Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase	0.933
CNR1	PDYN	ENSP00000358511	ENSP00000217305	cannabinoid receptor 1 (brain)	prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity)	0.948
CNR1	PENK	ENSP00000358511	ENSP00000324248	cannabinoid receptor 1 (brain)	proenkephalin; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum	0.948
CNR1	PNOC	ENSP00000358511	ENSP00000301908	cannabinoid receptor 1 (brain)	prepronociceptin; Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development (By similarity)	0.907
CNR1	POMC	ENSP00000358511	ENSP00000264708	cannabinoid receptor 1 (brain)	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.954
CNR1	RGS19	ENSP00000358511	ENSP00000333194	cannabinoid receptor 1 (brain)	regulator of G-protein signaling 19; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein	0.900
CNR1	SST	ENSP00000358511	ENSP00000287641	cannabinoid receptor 1 (brain)	somatostatin; Somatostatin inhibits the release of somatotropin	0.951
GAL	CNR1	ENSP00000265643	ENSP00000358511	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	cannabinoid receptor 1 (brain)	0.931
GAL	KNG1	ENSP00000265643	ENSP00000265023	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...]	0.954
GAL	NPY	ENSP00000265643	ENSP00000242152	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	0.990
GAL	OPRL1	ENSP00000265643	ENSP00000336764	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	opiate receptor-like 1; Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase	0.918
GAL	PDYN	ENSP00000265643	ENSP00000217305	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity)	0.971
GAL	PENK	ENSP00000265643	ENSP00000324248	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	proenkephalin; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum	0.949
GAL	PNOC	ENSP00000265643	ENSP00000301908	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	prepronociceptin; Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development (By similarity)	0.928
GAL	POMC	ENSP00000265643	ENSP00000264708	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.971
GAL	RGS19	ENSP00000265643	ENSP00000333194	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	regulator of G-protein signaling 19; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein	0.900
GAL	SST	ENSP00000265643	ENSP00000287641	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	somatostatin; Somatostatin inhibits the release of somatotropin	0.981

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