KIR2DL1 protein (Homo sapiens) - STRING network view

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KIR2DL1

killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis (348 aa)

Predicted Functional Partners:

HLA-C

0.974

PTPN11

0.821

KLRD1

0.720

NCR2

0.660

KLRC1

0.650

TRIM45

0.646

SORBS1

0.643

SPG20

0.637

HLA-E

0.635

NCAM1

0.583

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HLA-C	KIR2DL1	ENSP00000365402	ENSP00000336769	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	0.974
HLA-C	KLRC1	ENSP00000365402	ENSP00000352064	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.937
HLA-C	KLRD1	ENSP00000365402	ENSP00000338130	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	killer cell lectin-like receptor subfamily D, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.943
HLA-C	NCAM1	ENSP00000365402	ENSP00000318472	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	neural cell adhesion molecule 1	0.954
HLA-C	NCR2	ENSP00000365402	ENSP00000362181	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	natural cytotoxicity triggering receptor 2; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis	0.519
HLA-C	SORBS1	ENSP00000365402	ENSP00000355136	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	sorbin and SH3 domain containing 1	0.568
HLA-C	SPG20	ENSP00000365402	ENSP00000347314	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both	0.581
HLA-C	TRIM45	ENSP00000365402	ENSP00000256649	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway	0.565
HLA-E	KIR2DL1	ENSP00000365817	ENSP00000336769	major histocompatibility complex, class I, E	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	0.635
HLA-E	KLRC1	ENSP00000365817	ENSP00000352064	major histocompatibility complex, class I, E	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.988
HLA-E	KLRD1	ENSP00000365817	ENSP00000338130	major histocompatibility complex, class I, E	killer cell lectin-like receptor subfamily D, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.957
HLA-E	NCAM1	ENSP00000365817	ENSP00000318472	major histocompatibility complex, class I, E	neural cell adhesion molecule 1	0.638
HLA-E	NCR2	ENSP00000365817	ENSP00000362181	major histocompatibility complex, class I, E	natural cytotoxicity triggering receptor 2; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis	0.700
KIR2DL1	HLA-C	ENSP00000336769	ENSP00000365402	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.974
KIR2DL1	HLA-E	ENSP00000336769	ENSP00000365817	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	major histocompatibility complex, class I, E	0.635
KIR2DL1	KLRC1	ENSP00000336769	ENSP00000352064	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.650
KIR2DL1	KLRD1	ENSP00000336769	ENSP00000338130	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	killer cell lectin-like receptor subfamily D, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.720
KIR2DL1	NCAM1	ENSP00000336769	ENSP00000318472	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	neural cell adhesion molecule 1	0.583
KIR2DL1	NCR2	ENSP00000336769	ENSP00000362181	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	natural cytotoxicity triggering receptor 2; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis	0.660
KIR2DL1	PTPN11	ENSP00000336769	ENSP00000340944	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis	protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity	0.821

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