node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACHE | CHAT | ENSP00000303211 | ENSP00000337103 | acetylcholinesterase | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | 0.951 |
ACHE | SLC44A2 | ENSP00000303211 | ENSP00000336888 | acetylcholinesterase | solute carrier family 44, member 2 | 0.900 |
CDKN2D | GIPC3 | ENSP00000337056 | ENSP00000319254 | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); Interacts strongly with CDK4 and CDK6 and inhibits them | GIPC PDZ domain containing family, member 3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion (By similarity) | 0.590 |
CDKN2D | KEAP1 | ENSP00000337056 | ENSP00000171111 | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); Interacts strongly with CDK4 and CDK6 and inhibits them | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | 0.517 |
CDKN2D | SLC44A2 | ENSP00000337056 | ENSP00000336888 | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); Interacts strongly with CDK4 and CDK6 and inhibits them | solute carrier family 44, member 2 | 0.656 |
CHAT | ACHE | ENSP00000337103 | ENSP00000303211 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | acetylcholinesterase | 0.951 |
CHAT | SLC44A2 | ENSP00000337103 | ENSP00000336888 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | solute carrier family 44, member 2 | 0.900 |
COCH | SLC44A2 | ENSP00000216361 | ENSP00000336888 | coagulation factor C homolog, cochlin (Limulus polyphemus); Plays a role in the control of cell shape and motility in the trabecular meshwork | solute carrier family 44, member 2 | 0.878 |
GIPC3 | CDKN2D | ENSP00000319254 | ENSP00000337056 | GIPC PDZ domain containing family, member 3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion (By similarity) | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); Interacts strongly with CDK4 and CDK6 and inhibits them | 0.590 |
GIPC3 | KEAP1 | ENSP00000319254 | ENSP00000171111 | GIPC PDZ domain containing family, member 3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion (By similarity) | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | 0.649 |
GIPC3 | SLC44A2 | ENSP00000319254 | ENSP00000336888 | GIPC PDZ domain containing family, member 3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion (By similarity) | solute carrier family 44, member 2 | 0.782 |
KEAP1 | CDKN2D | ENSP00000171111 | ENSP00000337056 | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); Interacts strongly with CDK4 and CDK6 and inhibits them | 0.517 |
KEAP1 | GIPC3 | ENSP00000171111 | ENSP00000319254 | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | GIPC PDZ domain containing family, member 3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion (By similarity) | 0.649 |
KEAP1 | SLC44A2 | ENSP00000171111 | ENSP00000336888 | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | solute carrier family 44, member 2 | 0.683 |
LMOD1 | SLC44A2 | ENSP00000356257 | ENSP00000336888 | leiomodin 1 (smooth muscle) | solute carrier family 44, member 2 | 0.501 |
NABP1 | NABP2 | ENSP00000403683 | ENSP00000267023 | nucleic acid binding protein 1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...] | nucleic acid binding protein 2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...] | 0.905 |
NABP1 | SLC44A2 | ENSP00000403683 | ENSP00000336888 | nucleic acid binding protein 1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...] | solute carrier family 44, member 2 | 0.483 |
NABP2 | NABP1 | ENSP00000267023 | ENSP00000403683 | nucleic acid binding protein 2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...] | nucleic acid binding protein 1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...] | 0.905 |
NABP2 | SLC44A2 | ENSP00000267023 | ENSP00000336888 | nucleic acid binding protein 2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...] | solute carrier family 44, member 2 | 0.483 |
SLC44A2 | ACHE | ENSP00000336888 | ENSP00000303211 | solute carrier family 44, member 2 | acetylcholinesterase | 0.900 |