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STRINGSTRING
LMOD1 LMOD1 CHAT CHAT CDKN2D CDKN2D ACHE ACHE GIPC3 GIPC3 SLC44A2 SLC44A2 KEAP1 KEAP1 TMEM163 TMEM163 COCH COCH NABP2 NABP2 NABP1 NABP1
"SLC44A2" - solute carrier family 44, member 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
SLC44A2solute carrier family 44, member 2 (706 aa)    
Predicted Functional Partners:
CHAT
choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (748 aa)
          score_image score_image   0.900
ACHE
acetylcholinesterase (617 aa)
          score_image     0.900
COCH
coagulation factor C homolog, cochlin (Limulus polyphemus); Plays a role in the control of cell shape and motility in the trabecular meshwork (550 aa)
            score_image   0.878
GIPC3
GIPC PDZ domain containing family, member 3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion (By similarity) (312 aa)
            score_image   0.782
KEAP1
kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (624 aa)
            score_image   0.683
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); Interacts strongly with CDK4 and CDK6 and inhibits them (166 aa)
            score_image   0.656
TMEM163
transmembrane protein 163; May bind zinc and other divalent cations and recruit them to vesicular organelles (By similarity) (289 aa)
            score_image   0.592
LMOD1
leiomodin 1 (smooth muscle) (600 aa)
            score_image   0.501
NABP1
nucleic acid binding protein 1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...] (204 aa)
            score_image   0.483
NABP2
nucleic acid binding protein 2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...] (211 aa)
            score_image   0.483
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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