node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AR | GRB2 | ENSP00000363822 | ENSP00000339007 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.454 |
AR | PNRC1 | ENSP00000363822 | ENSP00000336931 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | 0.681 |
AR | RARA | ENSP00000363822 | ENSP00000254066 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | retinoic acid receptor, alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcrip [...] | 0.911 |
GRB2 | AR | ENSP00000339007 | ENSP00000363822 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.454 |
GRB2 | PNRC1 | ENSP00000339007 | ENSP00000336931 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | 0.621 |
PDCD5 | PNRC1 | ENSP00000466214 | ENSP00000336931 | programmed cell death 5; May function in the process of apoptosis | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | 0.558 |
PDCD5 | RASD1 | ENSP00000466214 | ENSP00000225688 | programmed cell death 5; May function in the process of apoptosis | RAS, dexamethasone-induced 1; Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity) | 0.568 |
PDCD5 | RASD2 | ENSP00000466214 | ENSP00000216127 | programmed cell death 5; May function in the process of apoptosis | RASD family, member 2; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination | 0.554 |
PNRC1 | AR | ENSP00000336931 | ENSP00000363822 | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.681 |
PNRC1 | GRB2 | ENSP00000336931 | ENSP00000339007 | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.621 |
PNRC1 | PDCD5 | ENSP00000336931 | ENSP00000466214 | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | programmed cell death 5; May function in the process of apoptosis | 0.558 |
PNRC1 | POLR3F | ENSP00000336931 | ENSP00000366828 | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcript [...] | 0.598 |
PNRC1 | PYURF | ENSP00000336931 | ENSP00000273968 | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | PIGY upstream reading frame | 0.532 |
PNRC1 | RARA | ENSP00000336931 | ENSP00000254066 | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | retinoic acid receptor, alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcrip [...] | 0.563 |
PNRC1 | RASD1 | ENSP00000336931 | ENSP00000225688 | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | RAS, dexamethasone-induced 1; Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity) | 0.590 |
PNRC1 | RASD2 | ENSP00000336931 | ENSP00000216127 | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | RASD family, member 2; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination | 0.583 |
PNRC1 | STS | ENSP00000336931 | ENSP00000217961 | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | steroid sulfatase (microsomal), isozyme S; Conversion of sulfated steroid precursors to estrogens during pregnancy | 0.751 |
PNRC1 | UPF1 | ENSP00000336931 | ENSP00000262803 | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | UPF1 regulator of nonsense transcripts homolog (yeast); RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1- eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (loc [...] | 0.568 |
POLR3F | PNRC1 | ENSP00000366828 | ENSP00000336931 | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcript [...] | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | 0.598 |
PYURF | PNRC1 | ENSP00000273968 | ENSP00000336931 | PIGY upstream reading frame | proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | 0.532 |