node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MYH6 | MYL3 | ENSP00000348634 | ENSP00000292327 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium | 0.981 |
MYH6 | TNNC1 | ENSP00000348634 | ENSP00000232975 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin C type 1 (slow); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments | 0.978 |
MYH6 | TNNI1 | ENSP00000348634 | ENSP00000337022 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin I type 1 (skeletal, slow) | 0.984 |
MYH6 | TNNT1 | ENSP00000348634 | ENSP00000467176 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin T type 1 (skeletal, slow); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.955 |
MYH6 | TNNT2 | ENSP00000348634 | ENSP00000356286 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin T type 2 (cardiac); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.987 |
MYH6 | TNNT3 | ENSP00000348634 | ENSP00000278317 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin T type 3 (skeletal, fast) | 0.976 |
MYH6 | TPM1 | ENSP00000348634 | ENSP00000267996 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | tropomyosin 1 (alpha) | 0.986 |
MYH6 | TPM2 | ENSP00000348634 | ENSP00000354219 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) | 0.973 |
MYH6 | TPM3 | ENSP00000348634 | ENSP00000357516 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | tropomyosin 3; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments | 0.986 |
MYH6 | TPM4 | ENSP00000348634 | ENSP00000345230 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | tropomyosin 4 | 0.961 |
MYL3 | MYH6 | ENSP00000292327 | ENSP00000348634 | myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | 0.981 |
MYL3 | TNNC1 | ENSP00000292327 | ENSP00000232975 | myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium | troponin C type 1 (slow); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments | 0.919 |
MYL3 | TNNI1 | ENSP00000292327 | ENSP00000337022 | myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium | troponin I type 1 (skeletal, slow) | 0.979 |
MYL3 | TNNT1 | ENSP00000292327 | ENSP00000467176 | myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium | troponin T type 1 (skeletal, slow); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.938 |
MYL3 | TNNT2 | ENSP00000292327 | ENSP00000356286 | myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium | troponin T type 2 (cardiac); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.976 |
MYL3 | TNNT3 | ENSP00000292327 | ENSP00000278317 | myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium | troponin T type 3 (skeletal, fast) | 0.945 |
MYL3 | TPM1 | ENSP00000292327 | ENSP00000267996 | myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium | tropomyosin 1 (alpha) | 0.975 |
MYL3 | TPM2 | ENSP00000292327 | ENSP00000354219 | myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium | tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) | 0.950 |
MYL3 | TPM3 | ENSP00000292327 | ENSP00000357516 | myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium | tropomyosin 3; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments | 0.975 |
MYL3 | TPM4 | ENSP00000292327 | ENSP00000345230 | myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium | tropomyosin 4 | 0.931 |