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STRINGSTRING
TNNT3 TNNT3 TPM3 TPM3 MYH6 MYH6 TPM2 TPM2 TNNT2 TNNT2 TNNT1 TNNT1 TPM1 TPM1 TNNC1 TNNC1 TPM4 TPM4 TNNI1 TNNI1 MYL3 MYL3
"TNNI1" - troponin I type 1 (skeletal, slow) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining edge
textmining
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co-expression
homology edge
protein homology
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Score
TNNI1troponin I type 1 (skeletal, slow) (187 aa)    
Predicted Functional Partners:
TNNT1
troponin T type 1 (skeletal, slow); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (278 aa)
      score_image score_image score_image score_image   0.999
TNNT2
troponin T type 2 (cardiac); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (288 aa)
      score_image score_image score_image score_image   0.999
TNNT3
troponin T type 3 (skeletal, fast) (258 aa)
      score_image score_image score_image score_image   0.999
TNNC1
troponin C type 1 (slow); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments (161 aa)
      score_image score_image score_image score_image   0.997
TPM3
tropomyosin 3; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (285 aa)
      score_image score_image score_image score_image   0.988
TPM2
tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) (284 aa)
      score_image score_image score_image score_image   0.987
TPM1
tropomyosin 1 (alpha) (284 aa)
      score_image score_image score_image score_image   0.986
MYH6
myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction (1939 aa)
      score_image score_image score_image score_image   0.984
TPM4
tropomyosin 4 (284 aa)
      score_image score_image score_image score_image   0.980
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium (195 aa)
      score_image score_image score_image score_image   0.979
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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