node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACHE | CHAT | ENSP00000303211 | ENSP00000337103 | acetylcholinesterase | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | 0.951 |
ACHE | CHKA | ENSP00000303211 | ENSP00000265689 | acetylcholinesterase | choline kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline | 0.931 |
ACHE | NTRK1 | ENSP00000303211 | ENSP00000431418 | acetylcholinesterase | neurotrophic tyrosine kinase, receptor, type 1 | 0.480 |
ACHE | SLC18A3 | ENSP00000303211 | ENSP00000363229 | acetylcholinesterase | solute carrier family 18 (vesicular acetylcholine), member 3; Involved in acetylcholine transport into synaptic vesicles | 0.730 |
ACHE | SLC44A1 | ENSP00000303211 | ENSP00000363852 | acetylcholinesterase | solute carrier family 44, member 1; Choline transporter. May be involved in membrane synthesis and myelin production | 0.905 |
CHAT | ACHE | ENSP00000337103 | ENSP00000303211 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | acetylcholinesterase | 0.951 |
CHAT | CHKA | ENSP00000337103 | ENSP00000265689 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | choline kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline | 0.932 |
CHAT | KIFAP3 | ENSP00000337103 | ENSP00000354560 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | kinesin-associated protein 3; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity) | 0.957 |
CHAT | NTRK1 | ENSP00000337103 | ENSP00000431418 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | neurotrophic tyrosine kinase, receptor, type 1 | 0.938 |
CHAT | RAB3A | ENSP00000337103 | ENSP00000222256 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal | 0.906 |
CHAT | SLC18A3 | ENSP00000337103 | ENSP00000363229 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | solute carrier family 18 (vesicular acetylcholine), member 3; Involved in acetylcholine transport into synaptic vesicles | 0.988 |
CHAT | SLC44A1 | ENSP00000337103 | ENSP00000363852 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | solute carrier family 44, member 1; Choline transporter. May be involved in membrane synthesis and myelin production | 0.901 |
CHAT | SLC5A7 | ENSP00000337103 | ENSP00000264047 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | solute carrier family 5 (choline transporter), member 7; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent | 0.954 |
CHAT | SYT1 | ENSP00000337103 | ENSP00000261205 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.920 |
CHAT | VAMP2 | ENSP00000337103 | ENSP00000314214 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.920 |
CHKA | ACHE | ENSP00000265689 | ENSP00000303211 | choline kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline | acetylcholinesterase | 0.931 |
CHKA | CHAT | ENSP00000265689 | ENSP00000337103 | choline kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | 0.932 |
KIFAP3 | CHAT | ENSP00000354560 | ENSP00000337103 | kinesin-associated protein 3; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity) | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | 0.957 |
NTRK1 | ACHE | ENSP00000431418 | ENSP00000303211 | neurotrophic tyrosine kinase, receptor, type 1 | acetylcholinesterase | 0.480 |
NTRK1 | CHAT | ENSP00000431418 | ENSP00000337103 | neurotrophic tyrosine kinase, receptor, type 1 | choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses | 0.938 |