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STRINGSTRING
CHKA CHKA SLC44A1 SLC44A1 ACHE ACHE NTRK1 NTRK1 KIFAP3 KIFAP3 CHAT CHAT SLC18A3 SLC18A3 SLC5A7 SLC5A7 RAB3A RAB3A SYT1 SYT1 VAMP2 VAMP2
"CHAT" - choline O-acetyltransferase in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
CHATcholine O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (748 aa)    
Predicted Functional Partners:
SLC18A3
solute carrier family 18 (vesicular acetylcholine), member 3; Involved in acetylcholine transport into synaptic vesicles (532 aa)
          score_image score_image   0.988
KIFAP3
kinesin-associated protein 3; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity) (792 aa)
            score_image   0.957
SLC5A7
solute carrier family 5 (choline transporter), member 7; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent (580 aa)
      score_image   score_image score_image   0.954
ACHE
acetylcholinesterase (617 aa)
            score_image   0.951
NTRK1
neurotrophic tyrosine kinase, receptor, type 1 (796 aa)
            score_image   0.938
CHKA
choline kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline (457 aa)
          score_image score_image   0.932
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane (116 aa)
          score_image score_image   0.920
SYT1
synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 (422 aa)
          score_image score_image   0.920
RAB3A
RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (220 aa)
          score_image score_image   0.906
SLC44A1
solute carrier family 44, member 1; Choline transporter. May be involved in membrane synthesis and myelin production (657 aa)
          score_image score_image   0.901
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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