node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM84B | FLRT1 | ENSP00000302578 | ENSP00000246841 | family with sequence similarity 84, member B | fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling | 0.540 |
FAM84B | MYADM | ENSP00000302578 | ENSP00000337222 | family with sequence similarity 84, member B | myeloid-associated differentiation marker | 0.528 |
FLRT1 | FAM84B | ENSP00000246841 | ENSP00000302578 | fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling | family with sequence similarity 84, member B | 0.540 |
FLRT1 | MYADM | ENSP00000246841 | ENSP00000337222 | fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling | myeloid-associated differentiation marker | 0.530 |
FLRT1 | SEPT11 | ENSP00000246841 | ENSP00000264893 | fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling | septin 11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy | 0.446 |
KIT | MYADM | ENSP00000288135 | ENSP00000337222 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinosit [...] | myeloid-associated differentiation marker | 0.607 |
KIT | NPM1 | ENSP00000288135 | ENSP00000296930 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinosit [...] | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.553 |
KIT | PLLP | ENSP00000288135 | ENSP00000219207 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinosit [...] | plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity) | 0.487 |
LYSMD1 | MYADM | ENSP00000357904 | ENSP00000337222 | LysM, putative peptidoglycan-binding, domain containing 1 | myeloid-associated differentiation marker | 0.468 |
MYADM | FAM84B | ENSP00000337222 | ENSP00000302578 | myeloid-associated differentiation marker | family with sequence similarity 84, member B | 0.528 |
MYADM | FLRT1 | ENSP00000337222 | ENSP00000246841 | myeloid-associated differentiation marker | fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling | 0.530 |
MYADM | KIT | ENSP00000337222 | ENSP00000288135 | myeloid-associated differentiation marker | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinosit [...] | 0.607 |
MYADM | LYSMD1 | ENSP00000337222 | ENSP00000357904 | myeloid-associated differentiation marker | LysM, putative peptidoglycan-binding, domain containing 1 | 0.468 |
MYADM | NCK2 | ENSP00000337222 | ENSP00000233154 | myeloid-associated differentiation marker | NCK adaptor protein 2; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling | 0.509 |
MYADM | NPM1 | ENSP00000337222 | ENSP00000296930 | myeloid-associated differentiation marker | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.459 |
MYADM | PLLP | ENSP00000337222 | ENSP00000219207 | myeloid-associated differentiation marker | plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity) | 0.862 |
MYADM | RRAGC | ENSP00000337222 | ENSP00000362092 | myeloid-associated differentiation marker | Ras-related GTP binding C; Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids | 0.485 |
MYADM | RRAGD | ENSP00000337222 | ENSP00000358423 | myeloid-associated differentiation marker | Ras-related GTP binding D; Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids | 0.614 |
MYADM | SEPT11 | ENSP00000337222 | ENSP00000264893 | myeloid-associated differentiation marker | septin 11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy | 0.430 |
NCK2 | MYADM | ENSP00000233154 | ENSP00000337222 | NCK adaptor protein 2; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling | myeloid-associated differentiation marker | 0.509 |