ZNF394 protein (Homo sapiens) - STRING network view

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ZNF394

zinc finger protein 394; May be involved in transcriptional regulation (561 aa)

Predicted Functional Partners:

XRN1

0.543

ENSG00000261611

0.504

KDM2A

0.501

FBXL19

0.501

KDM2B

0.501

MAP3K4

0.487

PTPN23

0.476

RANBP2

0.465

CLK2

0.436

CAPN13

0.430

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAPN13	ENSG00000261611	ENSP00000295055	ENSP00000463741	calpain 13; Probable non-lysosomal thiol-protease (By similarity)	Uncharacterized protein	0.430
CAPN13	PTPN23	ENSP00000295055	ENSP00000265562	calpain 13; Probable non-lysosomal thiol-protease (By similarity)	protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis	0.699
CAPN13	ZNF394	ENSP00000295055	ENSP00000337363	calpain 13; Probable non-lysosomal thiol-protease (By similarity)	zinc finger protein 394; May be involved in transcriptional regulation	0.430
CLK2	ZNF394	ENSP00000354856	ENSP00000337363	CDC-like kinase 2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B there [...]	zinc finger protein 394; May be involved in transcriptional regulation	0.436
ENSG00000261611	CAPN13	ENSP00000463741	ENSP00000295055	Uncharacterized protein	calpain 13; Probable non-lysosomal thiol-protease (By similarity)	0.430
ENSG00000261611	FBXL19	ENSP00000463741	ENSP00000369666	Uncharacterized protein	F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity)	0.501
ENSG00000261611	KDM2A	ENSP00000463741	ENSP00000432786	Uncharacterized protein	lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...]	0.501
ENSG00000261611	KDM2B	ENSP00000463741	ENSP00000366271	Uncharacterized protein	lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...]	0.501
ENSG00000261611	PTPN23	ENSP00000463741	ENSP00000265562	Uncharacterized protein	protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis	0.476
ENSG00000261611	RANBP2	ENSP00000463741	ENSP00000283195	Uncharacterized protein	RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB	0.465
ENSG00000261611	XRN1	ENSP00000463741	ENSP00000264951	Uncharacterized protein	5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)	0.543
ENSG00000261611	ZNF394	ENSP00000463741	ENSP00000337363	Uncharacterized protein	zinc finger protein 394; May be involved in transcriptional regulation	0.504
FBXL19	ENSG00000261611	ENSP00000369666	ENSP00000463741	F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity)	Uncharacterized protein	0.501
FBXL19	ZNF394	ENSP00000369666	ENSP00000337363	F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity)	zinc finger protein 394; May be involved in transcriptional regulation	0.501
KDM2A	ENSG00000261611	ENSP00000432786	ENSP00000463741	lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...]	Uncharacterized protein	0.501
KDM2A	ZNF394	ENSP00000432786	ENSP00000337363	lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...]	zinc finger protein 394; May be involved in transcriptional regulation	0.501
KDM2B	ENSG00000261611	ENSP00000366271	ENSP00000463741	lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...]	Uncharacterized protein	0.501
KDM2B	ZNF394	ENSP00000366271	ENSP00000337363	lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...]	zinc finger protein 394; May be involved in transcriptional regulation	0.501
MAP3K4	PTPN23	ENSP00000375986	ENSP00000265562	mitogen-activated protein kinase kinase kinase 4; Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6	protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis	0.590
MAP3K4	ZNF394	ENSP00000375986	ENSP00000337363	mitogen-activated protein kinase kinase kinase 4; Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6	zinc finger protein 394; May be involved in transcriptional regulation	0.487

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