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ZNF580 ZNF580 RAD51B RAD51B HMGA2 HMGA2 SUMO2 SUMO2 CCNB1IP1 CCNB1IP1 ALDH2 ALDH2 NF2 NF2 COX6C COX6C UBC UBC UBE2L3 UBE2L3 CCNB1 CCNB1
"CCNB1IP1" - cyclin B1 interacting protein 1, E3 ubiquitin protein ligase in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
coexpression edge
co-expression
homology edge
protein homology
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CCNB1IP1cyclin B1 interacting protein 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis (277 aa)    
Predicted Functional Partners:
SUMO2
SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] (95 aa)
         score_image   score_image   0.885
UBC
ubiquitin C (685 aa)
         score_image       0.765
COX6C
cytochrome c oxidase subunit VIc; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport (75 aa)
             score_image   0.751
HMGA2
high mobility group AT-hook 2; Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes (By similarity) (109 aa)
             score_image   0.743
CCNB1
cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition (433 aa)
         score_image   score_image   0.713
NF2
neurofibromin 2 (merlin) (595 aa)
         score_image   score_image   0.701
UBE2L3
ubiquitin-conjugating enzyme E2L 3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine- in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys-11’-linked polyubiquitination. Involved in th [...] (154 aa)
         score_image   score_image   0.687
ALDH2
aldehyde dehydrogenase 2 family (mitochondrial) (517 aa)
             score_image   0.660
RAD51B
RAD51 homolog B (S. cerevisiae) (384 aa)
             score_image   0.658
ZNF580
zinc finger protein 580; May be involved in transcriptional regulation (172 aa)
             score_image   0.628
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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