| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COL4A3BP | PCTP | ENSP00000369862 | ENSP00000268896 | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | phosphatidylcholine transfer protein; Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule | 0.520 |
| COL4A3BP | STARD3 | ENSP00000369862 | ENSP00000337446 | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | 0.733 |
| COL4A3BP | VAPA | ENSP00000369862 | ENSP00000345656 | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking | 0.910 |
| COL4A3BP | VAPB | ENSP00000369862 | ENSP00000417175 | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation | 0.573 |
| GRB7 | PGAP3 | ENSP00000403459 | ENSP00000300658 | growth factor receptor-bound protein 7 | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | 0.700 |
| GRB7 | STARD3 | ENSP00000403459 | ENSP00000337446 | growth factor receptor-bound protein 7 | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | 0.720 |
| NPC1 | NPC2 | ENSP00000269228 | ENSP00000451112 | Niemann-Pick disease, type C1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | Niemann-Pick disease, type C2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | 0.986 |
| NPC1 | STARD3 | ENSP00000269228 | ENSP00000337446 | Niemann-Pick disease, type C1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | 0.610 |
| NPC2 | NPC1 | ENSP00000451112 | ENSP00000269228 | Niemann-Pick disease, type C2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | Niemann-Pick disease, type C1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | 0.986 |
| NPC2 | STARD3 | ENSP00000451112 | ENSP00000337446 | Niemann-Pick disease, type C2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | 0.864 |
| NR1H3 | STARD3 | ENSP00000387946 | ENSP00000337446 | nuclear receptor subfamily 1, group H, member 3; Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | 0.857 |
| PCTP | COL4A3BP | ENSP00000268896 | ENSP00000369862 | phosphatidylcholine transfer protein; Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | 0.520 |
| PCTP | STARD3 | ENSP00000268896 | ENSP00000337446 | phosphatidylcholine transfer protein; Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | 0.760 |
| PGAP3 | GRB7 | ENSP00000300658 | ENSP00000403459 | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | growth factor receptor-bound protein 7 | 0.700 |
| PGAP3 | STARD3 | ENSP00000300658 | ENSP00000337446 | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | 0.731 |
| STARD3 | COL4A3BP | ENSP00000337446 | ENSP00000369862 | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | 0.733 |
| STARD3 | GRB7 | ENSP00000337446 | ENSP00000403459 | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | growth factor receptor-bound protein 7 | 0.720 |
| STARD3 | NPC1 | ENSP00000337446 | ENSP00000269228 | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | Niemann-Pick disease, type C1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | 0.610 |
| STARD3 | NPC2 | ENSP00000337446 | ENSP00000451112 | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | Niemann-Pick disease, type C2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | 0.864 |
| STARD3 | NR1H3 | ENSP00000337446 | ENSP00000387946 | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | nuclear receptor subfamily 1, group H, member 3; Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.857 |
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