| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASTN2 | CDH10 | ENSP00000354504 | ENSP00000264463 | astrotactin 2 | cadherin 10, type 2 (T2-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | 0.606 |
| ASTN2 | CDH9 | ENSP00000354504 | ENSP00000231021 | astrotactin 2 | cadherin 9, type 2 (T1-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | 0.606 |
| ASTN2 | CNTN4 | ENSP00000354504 | ENSP00000380602 | astrotactin 2 | contactin 4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis | 0.607 |
| ASTN2 | FBXO40 | ENSP00000354504 | ENSP00000337510 | astrotactin 2 | F-box protein 40; Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis (By similarity) | 0.607 |
| ASTN2 | NLGN1 | ENSP00000354504 | ENSP00000354541 | astrotactin 2 | neuroligin 1; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses (By similarity) | 0.606 |
| ASTN2 | RFWD2 | ENSP00000354504 | ENSP00000356641 | astrotactin 2 | ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediat [...] | 0.589 |
| ASTN2 | TAS2R1 | ENSP00000354504 | ENSP00000371932 | astrotactin 2 | taste receptor, type 2, member 1; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 | 0.606 |
| CDH10 | ASTN2 | ENSP00000264463 | ENSP00000354504 | cadherin 10, type 2 (T2-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | astrotactin 2 | 0.606 |
| CDH10 | CDH9 | ENSP00000264463 | ENSP00000231021 | cadherin 10, type 2 (T2-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | cadherin 9, type 2 (T1-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | 0.956 |
| CDH10 | CNTN4 | ENSP00000264463 | ENSP00000380602 | cadherin 10, type 2 (T2-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | contactin 4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis | 0.576 |
| CDH10 | FBXO40 | ENSP00000264463 | ENSP00000337510 | cadherin 10, type 2 (T2-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | F-box protein 40; Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis (By similarity) | 0.590 |
| CDH10 | NLGN1 | ENSP00000264463 | ENSP00000354541 | cadherin 10, type 2 (T2-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | neuroligin 1; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses (By similarity) | 0.561 |
| CDH10 | RFWD2 | ENSP00000264463 | ENSP00000356641 | cadherin 10, type 2 (T2-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediat [...] | 0.562 |
| CDH10 | TAS2R1 | ENSP00000264463 | ENSP00000371932 | cadherin 10, type 2 (T2-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | taste receptor, type 2, member 1; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 | 0.568 |
| CDH9 | ASTN2 | ENSP00000231021 | ENSP00000354504 | cadherin 9, type 2 (T1-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | astrotactin 2 | 0.606 |
| CDH9 | CDH10 | ENSP00000231021 | ENSP00000264463 | cadherin 9, type 2 (T1-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | cadherin 10, type 2 (T2-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | 0.956 |
| CDH9 | CNTN4 | ENSP00000231021 | ENSP00000380602 | cadherin 9, type 2 (T1-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | contactin 4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis | 0.576 |
| CDH9 | FBXO40 | ENSP00000231021 | ENSP00000337510 | cadherin 9, type 2 (T1-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | F-box protein 40; Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis (By similarity) | 0.603 |
| CDH9 | NLGN1 | ENSP00000231021 | ENSP00000354541 | cadherin 9, type 2 (T1-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | neuroligin 1; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses (By similarity) | 0.561 |
| CDH9 | RFWD2 | ENSP00000231021 | ENSP00000356641 | cadherin 9, type 2 (T1-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediat [...] | 0.563 |
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