| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AASDHPPT | EBAG9 | ENSP00000278618 | ENSP00000337675 | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4’- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | 0.570 |
| CHUK | EBAG9 | ENSP00000359424 | ENSP00000337675 | conserved helix-loop-helix ubiquitous kinase; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus [...] | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | 0.906 |
| CHUK | ESR1 | ENSP00000359424 | ENSP00000206249 | conserved helix-loop-helix ubiquitous kinase; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus [...] | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | 0.690 |
| CHUK | NCOA3 | ENSP00000359424 | ENSP00000361066 | conserved helix-loop-helix ubiquitous kinase; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus [...] | nuclear receptor coactivator 3 | 0.975 |
| COX7A2L | EBAG9 | ENSP00000234301 | ENSP00000337675 | cytochrome c oxidase subunit VIIa polypeptide 2 like; May be a regulatory subunit of cytochrome c oxidase that mediates the higher level of energy production in target cells by estrogen | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | 0.886 |
| COX7A2L | GRIN2D | ENSP00000234301 | ENSP00000263269 | cytochrome c oxidase subunit VIIa polypeptide 2 like; May be a regulatory subunit of cytochrome c oxidase that mediates the higher level of energy production in target cells by estrogen | glutamate receptor, ionotropic, N-methyl D-aspartate 2D; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine | 0.811 |
| DPP3 | EBAG9 | ENSP00000353701 | ENSP00000337675 | dipeptidyl-peptidase 3; Cleaves Arg-Arg-beta-naphthylamide | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | 0.708 |
| EBAG9 | AASDHPPT | ENSP00000337675 | ENSP00000278618 | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4’- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN | 0.570 |
| EBAG9 | CHUK | ENSP00000337675 | ENSP00000359424 | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | conserved helix-loop-helix ubiquitous kinase; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus [...] | 0.906 |
| EBAG9 | COX7A2L | ENSP00000337675 | ENSP00000234301 | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | cytochrome c oxidase subunit VIIa polypeptide 2 like; May be a regulatory subunit of cytochrome c oxidase that mediates the higher level of energy production in target cells by estrogen | 0.886 |
| EBAG9 | DPP3 | ENSP00000337675 | ENSP00000353701 | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | dipeptidyl-peptidase 3; Cleaves Arg-Arg-beta-naphthylamide | 0.708 |
| EBAG9 | ESR1 | ENSP00000337675 | ENSP00000206249 | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | 0.929 |
| EBAG9 | GRIN2D | ENSP00000337675 | ENSP00000263269 | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | glutamate receptor, ionotropic, N-methyl D-aspartate 2D; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine | 0.815 |
| EBAG9 | NCOA3 | ENSP00000337675 | ENSP00000361066 | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | nuclear receptor coactivator 3 | 0.919 |
| EBAG9 | NINL | ENSP00000337675 | ENSP00000278886 | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | ninein-like; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis | 0.599 |
| EBAG9 | SMAD4 | ENSP00000337675 | ENSP00000341551 | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] | 0.905 |
| EBAG9 | SNAPIN | ENSP00000337675 | ENSP00000357674 | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | SNAP-associated protein; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May modulate a step between vesicle priming, fusion [...] | 0.970 |
| ESR1 | CHUK | ENSP00000206249 | ENSP00000359424 | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | conserved helix-loop-helix ubiquitous kinase; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus [...] | 0.690 |
| ESR1 | EBAG9 | ENSP00000206249 | ENSP00000337675 | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | estrogen receptor binding site associated, antigen, 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases | 0.929 |
| ESR1 | NCOA3 | ENSP00000206249 | ENSP00000361066 | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | nuclear receptor coactivator 3 | 0.999 |
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