Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SEC62 | SEC62 homolog (S. cerevisiae); Required for preprotein translocation (By similarity) (399 aa) | ||||||||||||
Predicted Functional Partners:
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 | SEC63 | SEC63 homolog (S. cerevisiae); Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane (760 aa) |
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0.999 | |||||||
 | SEC61G | Sec61 gamma subunit; Necessary for protein translocation in the endoplasmic reticulum (By similarity) (68 aa) |
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0.992 | |||||||||
 | SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) (476 aa) |
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0.967 | |||||||||
 | SEC61B | Sec61 beta subunit; Necessary for protein translocation in the endoplasmic reticulum (96 aa) |
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0.955 | |||||||||
 | SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) (169 aa) |
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0.954 | |||||||||
 | UBC | ubiquitin C (685 aa) |
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0.881 | ||||||||||
 | SEC61A2 | Sec61 alpha 2 subunit (S. cerevisiae); Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity) (476 aa) |
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0.774 | |||||||||
 | EXD2 | exonuclease 3’-5’ domain containing 2 (621 aa) |
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0.681 | ||||||||||
 | TMEM214 | transmembrane protein 214 (689 aa) |
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0.681 | ||||||||||
 | DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1; May modulate protein synthesis (By similarity) (554 aa) |
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0.636 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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