node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLIC1 | MAPK15 | ENSP00000364934 | ENSP00000337691 | chloride intracellular channel 1 | mitogen-activated protein kinase 15; In vitro, phosphorylates MBP | 0.745 |
CLIC3 | MAPK15 | ENSP00000419378 | ENSP00000337691 | chloride intracellular channel 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control | mitogen-activated protein kinase 15; In vitro, phosphorylates MBP | 0.976 |
DUSP1 | DUSP4 | ENSP00000239223 | ENSP00000240100 | dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity) | dual specificity phosphatase 4; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2 | 0.902 |
DUSP1 | JUN | ENSP00000239223 | ENSP00000360266 | dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity) | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | 0.988 |
DUSP1 | MAPK15 | ENSP00000239223 | ENSP00000337691 | dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity) | mitogen-activated protein kinase 15; In vitro, phosphorylates MBP | 0.870 |
DUSP1 | MBP | ENSP00000239223 | ENSP00000372025 | dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity) | myelin basic protein | 0.506 |
DUSP1 | PTPN23 | ENSP00000239223 | ENSP00000265562 | dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity) | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.538 |
DUSP4 | DUSP1 | ENSP00000240100 | ENSP00000239223 | dual specificity phosphatase 4; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2 | dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity) | 0.902 |
DUSP4 | JUN | ENSP00000240100 | ENSP00000360266 | dual specificity phosphatase 4; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2 | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | 0.524 |
DUSP4 | MAPK15 | ENSP00000240100 | ENSP00000337691 | dual specificity phosphatase 4; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2 | mitogen-activated protein kinase 15; In vitro, phosphorylates MBP | 0.796 |
DUSP4 | PTPN23 | ENSP00000240100 | ENSP00000265562 | dual specificity phosphatase 4; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.541 |
JUN | DUSP1 | ENSP00000360266 | ENSP00000239223 | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity) | 0.988 |
JUN | DUSP4 | ENSP00000360266 | ENSP00000240100 | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | dual specificity phosphatase 4; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2 | 0.524 |
JUN | MAPK15 | ENSP00000360266 | ENSP00000337691 | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | mitogen-activated protein kinase 15; In vitro, phosphorylates MBP | 0.948 |
JUN | MBP | ENSP00000360266 | ENSP00000372025 | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | myelin basic protein | 0.723 |
JUN | MEF2A | ENSP00000360266 | ENSP00000346389 | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | myocyte enhancer factor 2A | 0.991 |
JUN | PCNA | ENSP00000360266 | ENSP00000368438 | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | 0.659 |
MAPK15 | CLIC1 | ENSP00000337691 | ENSP00000364934 | mitogen-activated protein kinase 15; In vitro, phosphorylates MBP | chloride intracellular channel 1 | 0.745 |
MAPK15 | CLIC3 | ENSP00000337691 | ENSP00000419378 | mitogen-activated protein kinase 15; In vitro, phosphorylates MBP | chloride intracellular channel 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control | 0.976 |
MAPK15 | DUSP1 | ENSP00000337691 | ENSP00000239223 | mitogen-activated protein kinase 15; In vitro, phosphorylates MBP | dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity) | 0.870 |