| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HSD17B1 | MLX | ENSP00000466799 | ENSP00000246912 | hydroxysteroid (17-beta) dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH | MLX, MAX dimerization protein | 0.661 |
| HSD17B1 | MLXIP | ENSP00000466799 | ENSP00000312834 | hydroxysteroid (17-beta) dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH | MLX interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5’-CACGTG-3’. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation | 0.685 |
| HSD17B1 | MNT | ENSP00000466799 | ENSP00000174618 | hydroxysteroid (17-beta) dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH | MNT, MAX dimerization protein; Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5’-CACGTG-3’ and, with higher affinity, to 5’-CACGCG-3’ | 0.418 |
| HSD17B1 | MXD4 | ENSP00000466799 | ENSP00000337889 | hydroxysteroid (17-beta) dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH | MAX dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity) | 0.661 |
| MAX | MNT | ENSP00000351490 | ENSP00000174618 | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | MNT, MAX dimerization protein; Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5’-CACGTG-3’ and, with higher affinity, to 5’-CACGCG-3’ | 0.898 |
| MAX | MXD4 | ENSP00000351490 | ENSP00000337889 | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | MAX dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity) | 0.997 |
| MAX | MYC | ENSP00000351490 | ENSP00000367207 | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.999 |
| MAX | SIN3A | ENSP00000351490 | ENSP00000353622 | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | SIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation | 0.916 |
| MAX | ZBTB17 | ENSP00000351490 | ENSP00000364895 | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | zinc finger and BTB domain containing 17; Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment (By similarity). Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during [...] | 0.954 |
| MLX | HSD17B1 | ENSP00000246912 | ENSP00000466799 | MLX, MAX dimerization protein | hydroxysteroid (17-beta) dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH | 0.661 |
| MLX | MLXIP | ENSP00000246912 | ENSP00000312834 | MLX, MAX dimerization protein | MLX interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5’-CACGTG-3’. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation | 0.942 |
| MLX | MNT | ENSP00000246912 | ENSP00000174618 | MLX, MAX dimerization protein | MNT, MAX dimerization protein; Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5’-CACGTG-3’ and, with higher affinity, to 5’-CACGCG-3’ | 0.951 |
| MLX | MXD4 | ENSP00000246912 | ENSP00000337889 | MLX, MAX dimerization protein | MAX dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity) | 0.988 |
| MLX | NIF3L1 | ENSP00000246912 | ENSP00000386394 | MLX, MAX dimerization protein | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 0.751 |
| MLX | SIN3A | ENSP00000246912 | ENSP00000353622 | MLX, MAX dimerization protein | SIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation | 0.455 |
| MLXIP | HSD17B1 | ENSP00000312834 | ENSP00000466799 | MLX interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5’-CACGTG-3’. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation | hydroxysteroid (17-beta) dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH | 0.685 |
| MLXIP | MLX | ENSP00000312834 | ENSP00000246912 | MLX interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5’-CACGTG-3’. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation | MLX, MAX dimerization protein | 0.942 |
| MLXIP | MNT | ENSP00000312834 | ENSP00000174618 | MLX interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5’-CACGTG-3’. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation | MNT, MAX dimerization protein; Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5’-CACGTG-3’ and, with higher affinity, to 5’-CACGCG-3’ | 0.639 |
| MLXIP | MXD4 | ENSP00000312834 | ENSP00000337889 | MLX interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5’-CACGTG-3’. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation | MAX dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity) | 0.776 |
| MLXIP | SIN3A | ENSP00000312834 | ENSP00000353622 | MLX interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5’-CACGTG-3’. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation | SIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation | 0.511 |
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