node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY9 | AVP | ENSP00000294016 | ENSP00000369647 | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | 0.913 |
ADCY9 | CRH | ENSP00000294016 | ENSP00000276571 | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | 0.901 |
ADCY9 | CRHR2 | ENSP00000294016 | ENSP00000340943 | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | corticotropin releasing hormone receptor 2; This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.907 |
ADCY9 | GCG | ENSP00000294016 | ENSP00000387662 | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life | 0.911 |
ADCY9 | HTR7 | ENSP00000294016 | ENSP00000337949 | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase | 0.938 |
ADCY9 | NPS | ENSP00000294016 | ENSP00000381105 | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.904 |
ADCY9 | POMC | ENSP00000294016 | ENSP00000264708 | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.907 |
ADCY9 | PTGIR | ENSP00000294016 | ENSP00000291294 | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | prostaglandin I2 (prostacyclin) receptor (IP); Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase | 0.903 |
ADCY9 | VIP | ENSP00000294016 | ENSP00000356213 | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder | 0.905 |
AVP | ADCY9 | ENSP00000369647 | ENSP00000294016 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | 0.913 |
AVP | CRH | ENSP00000369647 | ENSP00000276571 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | 0.997 |
AVP | CRHR2 | ENSP00000369647 | ENSP00000340943 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | corticotropin releasing hormone receptor 2; This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.944 |
AVP | GCG | ENSP00000369647 | ENSP00000387662 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life | 0.963 |
AVP | HTR7 | ENSP00000369647 | ENSP00000337949 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase | 0.951 |
AVP | NPS | ENSP00000369647 | ENSP00000381105 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.980 |
AVP | POMC | ENSP00000369647 | ENSP00000264708 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.987 |
AVP | PTGIR | ENSP00000369647 | ENSP00000291294 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | prostaglandin I2 (prostacyclin) receptor (IP); Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase | 0.927 |
AVP | VIP | ENSP00000369647 | ENSP00000356213 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder | 0.963 |
CRH | ADCY9 | ENSP00000276571 | ENSP00000294016 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity) | 0.901 |
CRH | AVP | ENSP00000276571 | ENSP00000369647 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | 0.997 |