Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | MRPL30 | mitochondrial ribosomal protein L30 (161 aa) | ||||||||||||
Predicted Functional Partners:
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 | MRPL38 | mitochondrial ribosomal protein L38 (380 aa) |
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0.788 | ||||||||
 | MRPS14 | mitochondrial ribosomal protein S14 (128 aa) |
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0.761 | ||||||||||
 | MRPL13 | mitochondrial ribosomal protein L13 (178 aa) |
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0.728 | |||||||||
 | MRPS16 | mitochondrial ribosomal protein S16 (137 aa) |
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0.719 | |||||||||
 | MRPL1 | mitochondrial ribosomal protein L1 (325 aa) |
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0.714 | |||||||||
 | MRPS18C | mitochondrial ribosomal protein S18C (142 aa) |
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0.682 | |||||||||
 | BACE1 | beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (501 aa) |
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0.651 | ||||||||||
 | MRPL42 | mitochondrial ribosomal protein L42 (142 aa) |
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0.645 | |||||||||
 | MARCKSL1 | MARCKS-like 1; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity) (195 aa) |
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0.644 | ||||||||||
 | SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) (362 aa) |
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0.644 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
