node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | AQP2 | ENSP00000355627 | ENSP00000199280 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient | 0.872 |
AGT | AVP | ENSP00000355627 | ENSP00000369647 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | 0.949 |
AGT | AVPR2 | ENSP00000355627 | ENSP00000338072 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | arginine vasopressin receptor 2; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption | 0.804 |
AQP2 | AGT | ENSP00000199280 | ENSP00000355627 | aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.872 |
AQP2 | AVP | ENSP00000199280 | ENSP00000369647 | aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | 0.975 |
AQP2 | AVPR2 | ENSP00000199280 | ENSP00000338072 | aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient | arginine vasopressin receptor 2; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption | 0.727 |
AQP2 | CLCNKA | ENSP00000199280 | ENSP00000332771 | aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient | chloride channel, voltage-sensitive Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms | 0.639 |
ARHGAP4 | AVPR2 | ENSP00000359045 | ENSP00000338072 | Rho GTPase activating protein 4; Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells | arginine vasopressin receptor 2; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption | 0.700 |
ARHGAP4 | RENBP | ENSP00000359045 | ENSP00000377303 | Rho GTPase activating protein 4; Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells | renin binding protein; Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway- although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded | 0.705 |
ARHGAP4 | TMEM187 | ENSP00000359045 | ENSP00000358999 | Rho GTPase activating protein 4; Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells | transmembrane protein 187 | 0.585 |
AVP | AGT | ENSP00000369647 | ENSP00000355627 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.949 |
AVP | AQP2 | ENSP00000369647 | ENSP00000199280 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient | 0.975 |
AVP | AVPR2 | ENSP00000369647 | ENSP00000338072 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | arginine vasopressin receptor 2; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption | 0.720 |
AVPR2 | AGT | ENSP00000338072 | ENSP00000355627 | arginine vasopressin receptor 2; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.804 |
AVPR2 | AQP2 | ENSP00000338072 | ENSP00000199280 | arginine vasopressin receptor 2; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption | aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient | 0.727 |
AVPR2 | ARHGAP4 | ENSP00000338072 | ENSP00000359045 | arginine vasopressin receptor 2; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption | Rho GTPase activating protein 4; Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells | 0.700 |
AVPR2 | AVP | ENSP00000338072 | ENSP00000369647 | arginine vasopressin receptor 2; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | 0.720 |
AVPR2 | CLCNKA | ENSP00000338072 | ENSP00000332771 | arginine vasopressin receptor 2; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption | chloride channel, voltage-sensitive Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms | 0.518 |
AVPR2 | GPRASP1 | ENSP00000338072 | ENSP00000355146 | arginine vasopressin receptor 2; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption | G protein-coupled receptor associated sorting protein 1; May modulate lysosomal sorting and functional down- regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes | 0.681 |
AVPR2 | HCFC1 | ENSP00000338072 | ENSP00000309555 | arginine vasopressin receptor 2; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption | host cell factor C1 (VP16-accessory protein); Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 ’Lys-4’ methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional a [...] | 0.562 |