node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF2 | HBG2 | ENSP00000264110 | ENSP00000338082 | activating transcription factor 2; Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex | hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains | 0.900 |
ATF2 | JUN | ENSP00000264110 | ENSP00000360266 | activating transcription factor 2; Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | 0.999 |
HBA2 | HBB | ENSP00000251595 | ENSP00000333994 | hemoglobin, alpha 2 | hemoglobin, beta | 0.997 |
HBA2 | HBD | ENSP00000251595 | ENSP00000369654 | hemoglobin, alpha 2 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | 0.983 |
HBA2 | HBE1 | ENSP00000251595 | ENSP00000292896 | hemoglobin, alpha 2 | hemoglobin, epsilon 1; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin | 0.927 |
HBA2 | HBG2 | ENSP00000251595 | ENSP00000338082 | hemoglobin, alpha 2 | hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains | 0.982 |
HBB | HBA2 | ENSP00000333994 | ENSP00000251595 | hemoglobin, beta | hemoglobin, alpha 2 | 0.997 |
HBB | HBD | ENSP00000333994 | ENSP00000369654 | hemoglobin, beta | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | 0.901 |
HBB | HBE1 | ENSP00000333994 | ENSP00000292896 | hemoglobin, beta | hemoglobin, epsilon 1; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin | 0.901 |
HBB | HBG2 | ENSP00000333994 | ENSP00000338082 | hemoglobin, beta | hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains | 0.956 |
HBB | MAFF | ENSP00000333994 | ENSP00000345393 | hemoglobin, beta | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian); Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response | 0.903 |
HBB | MAFG | ENSP00000333994 | ENSP00000350369 | hemoglobin, beta | v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian); Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates glob [...] | 0.901 |
HBB | MAFK | ENSP00000333994 | ENSP00000344903 | hemoglobin, beta | v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian); Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor | 0.909 |
HBB | NFE2 | ENSP00000333994 | ENSP00000312436 | hemoglobin, beta | nuclear factor (erythroid-derived 2), 45kDa; Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron | 0.941 |
HBD | HBA2 | ENSP00000369654 | ENSP00000251595 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | hemoglobin, alpha 2 | 0.983 |
HBD | HBB | ENSP00000369654 | ENSP00000333994 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | hemoglobin, beta | 0.901 |
HBD | HBE1 | ENSP00000369654 | ENSP00000292896 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | hemoglobin, epsilon 1; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin | 0.901 |
HBD | HBG2 | ENSP00000369654 | ENSP00000338082 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains | 0.901 |
HBD | MAFF | ENSP00000369654 | ENSP00000345393 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian); Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response | 0.904 |
HBD | MAFG | ENSP00000369654 | ENSP00000350369 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian); Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates glob [...] | 0.902 |