node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPRS | FARS2 | ENSP00000355890 | ENSP00000274680 | glutamyl-prolyl-tRNA synthetase | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | 0.891 |
EPRS | FARSA | ENSP00000355890 | ENSP00000320309 | glutamyl-prolyl-tRNA synthetase | phenylalanyl-tRNA synthetase, alpha subunit | 0.841 |
EPRS | HARS | ENSP00000355890 | ENSP00000425634 | glutamyl-prolyl-tRNA synthetase | histidyl-tRNA synthetase | 0.857 |
EPRS | HARS2 | ENSP00000355890 | ENSP00000230771 | glutamyl-prolyl-tRNA synthetase | histidyl-tRNA synthetase 2, mitochondrial | 0.827 |
EPRS | IARS | ENSP00000355890 | ENSP00000364794 | glutamyl-prolyl-tRNA synthetase | isoleucyl-tRNA synthetase | 0.999 |
EPRS | KARS | ENSP00000355890 | ENSP00000325448 | glutamyl-prolyl-tRNA synthetase | lysyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), th [...] | 0.999 |
EPRS | NARS | ENSP00000355890 | ENSP00000256854 | glutamyl-prolyl-tRNA synthetase | asparaginyl-tRNA synthetase | 0.999 |
EPRS | SARS | ENSP00000355890 | ENSP00000234677 | glutamyl-prolyl-tRNA synthetase | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) | 0.815 |
EPRS | TARSL2 | ENSP00000355890 | ENSP00000338093 | glutamyl-prolyl-tRNA synthetase | threonyl-tRNA synthetase-like 2 | 0.965 |
EPRS | YARS | ENSP00000355890 | ENSP00000362576 | glutamyl-prolyl-tRNA synthetase | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.998 |
FARS2 | EPRS | ENSP00000274680 | ENSP00000355890 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | glutamyl-prolyl-tRNA synthetase | 0.891 |
FARS2 | FARSA | ENSP00000274680 | ENSP00000320309 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | phenylalanyl-tRNA synthetase, alpha subunit | 0.947 |
FARS2 | HARS | ENSP00000274680 | ENSP00000425634 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | histidyl-tRNA synthetase | 0.853 |
FARS2 | HARS2 | ENSP00000274680 | ENSP00000230771 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | histidyl-tRNA synthetase 2, mitochondrial | 0.766 |
FARS2 | IARS | ENSP00000274680 | ENSP00000364794 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | isoleucyl-tRNA synthetase | 0.954 |
FARS2 | KARS | ENSP00000274680 | ENSP00000325448 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | lysyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), th [...] | 0.860 |
FARS2 | NARS | ENSP00000274680 | ENSP00000256854 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | asparaginyl-tRNA synthetase | 0.855 |
FARS2 | SARS | ENSP00000274680 | ENSP00000234677 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) | 0.876 |
FARS2 | TARSL2 | ENSP00000274680 | ENSP00000338093 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | threonyl-tRNA synthetase-like 2 | 0.905 |
FARS2 | YARS | ENSP00000274680 | ENSP00000362576 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.995 |