node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DGKI | PLCB1 | ENSP00000288490 | ENSP00000338185 | diacylglycerol kinase, iota | phospholipase C, beta 1 (phosphoinositide-specific) | 0.955 |
DGKZ | GNA11 | ENSP00000412178 | ENSP00000078429 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.513 |
DGKZ | PLCB1 | ENSP00000412178 | ENSP00000338185 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | phospholipase C, beta 1 (phosphoinositide-specific) | 0.955 |
DGKZ | PRKCA | ENSP00000412178 | ENSP00000408695 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | 0.583 |
GNA11 | DGKZ | ENSP00000078429 | ENSP00000412178 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | 0.513 |
GNA11 | GNA14 | ENSP00000078429 | ENSP00000365807 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.900 |
GNA11 | GNAQ | ENSP00000078429 | ENSP00000286548 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | 0.900 |
GNA11 | ITPR1 | ENSP00000078429 | ENSP00000306253 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | inositol 1,4,5-trisphosphate receptor, type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity) | 0.583 |
GNA11 | ITPR2 | ENSP00000078429 | ENSP00000370744 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) | 0.480 |
GNA11 | ITPR3 | ENSP00000078429 | ENSP00000363435 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium | 0.553 |
GNA11 | PLCB1 | ENSP00000078429 | ENSP00000338185 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | phospholipase C, beta 1 (phosphoinositide-specific) | 0.986 |
GNA11 | PRKCA | ENSP00000078429 | ENSP00000408695 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | 0.454 |
GNA14 | GNA11 | ENSP00000365807 | ENSP00000078429 | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.900 |
GNA14 | GNAQ | ENSP00000365807 | ENSP00000286548 | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | 0.900 |
GNA14 | ITPR1 | ENSP00000365807 | ENSP00000306253 | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | inositol 1,4,5-trisphosphate receptor, type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity) | 0.430 |
GNA14 | ITPR2 | ENSP00000365807 | ENSP00000370744 | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) | 0.430 |
GNA14 | ITPR3 | ENSP00000365807 | ENSP00000363435 | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium | 0.430 |
GNA14 | PLCB1 | ENSP00000365807 | ENSP00000338185 | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | phospholipase C, beta 1 (phosphoinositide-specific) | 0.962 |
GNAQ | GNA11 | ENSP00000286548 | ENSP00000078429 | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.900 |
GNAQ | GNA14 | ENSP00000286548 | ENSP00000365807 | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | guanine nucleotide binding protein (G protein), alpha 14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.900 |